2v4j A 2.1 BS01 SF4 A 1 C177 C183 F185 A186 A220 C221 N223 C225 C176 C182 F184 A185 A219 C220 N222 C224 1.8.99.3 0000103,0005515,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45574 18829451 501 AKHATPKLDQLESGPWPSFVSDIKQEAAYRAANPKGLDYQVPVDCPEDLLGVLELSYDEGETHWKHGGIVGVFGYGGGVIGRYCDQPEKFPGVAHFHTVRVAQPSGKYYSADYLRQLCDIWDLRGSGLTNMHGSTGDIVLLGTQTPQLEEIFFELTHNLNTDLGGSGSNLRTPESCLGKSRCEFACYDSQAACYELTMEYQDELHRPAFPYKFKFKFDACPNGCVASIARSDFSVIGTWKDDIKIDAEAVKAYVAGEFKPNAGAHSGRDWGKFDIEAEVVNRCPSKCMKWDGSKLSIDNKECVRCMHCINTMPRALHIGDERGASILCGAKAPILDGAQMGSLLVPFVAAEEPFDEIKEVVEKIWDWWMEEGKNRERLGETMKRLSFQKLLEVTEIAPVPQHVKEPRTNPYIFFKEEEVPGGWDRDITEYRKRHLR 2v4j A 2.1 BS02 SF4 A 2 C284 P285 C288 M289 C303 V304 R305 C306 M307 C309 C283 P284 C287 M288 C302 V303 R304 C305 M306 C308 1.8.99.3 0000103,0005515,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45574 18829451 502 AKHATPKLDQLESGPWPSFVSDIKQEAAYRAANPKGLDYQVPVDCPEDLLGVLELSYDEGETHWKHGGIVGVFGYGGGVIGRYCDQPEKFPGVAHFHTVRVAQPSGKYYSADYLRQLCDIWDLRGSGLTNMHGSTGDIVLLGTQTPQLEEIFFELTHNLNTDLGGSGSNLRTPESCLGKSRCEFACYDSQAACYELTMEYQDELHRPAFPYKFKFKFDACPNGCVASIARSDFSVIGTWKDDIKIDAEAVKAYVAGEFKPNAGAHSGRDWGKFDIEAEVVNRCPSKCMKWDGSKLSIDNKECVRCMHCINTMPRALHIGDERGASILCGAKAPILDGAQMGSLLVPFVAAEEPFDEIKEVVEKIWDWWMEEGKNRERLGETMKRLSFQKLLEVTEIAPVPQHVKEPRTNPYIFFKEEEVPGGWDRDITEYRKRHLR 2v4j A 2.1 BS03 SH0 A 1 C177 L178 C183 E184 G224 C225 N262 N311 C176 L177 C182 E183 G223 C224 N261 N310 1.8.99.3 0000103,0005515,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45574 18829451 503 AKHATPKLDQLESGPWPSFVSDIKQEAAYRAANPKGLDYQVPVDCPEDLLGVLELSYDEGETHWKHGGIVGVFGYGGGVIGRYCDQPEKFPGVAHFHTVRVAQPSGKYYSADYLRQLCDIWDLRGSGLTNMHGSTGDIVLLGTQTPQLEEIFFELTHNLNTDLGGSGSNLRTPESCLGKSRCEFACYDSQAACYELTMEYQDELHRPAFPYKFKFKFDACPNGCVASIARSDFSVIGTWKDDIKIDAEAVKAYVAGEFKPNAGAHSGRDWGKFDIEAEVVNRCPSKCMKWDGSKLSIDNKECVRCMHCINTMPRALHIGDERGASILCGAKAPILDGAQMGSLLVPFVAAEEPFDEIKEVVEKIWDWWMEEGKNRERLGETMKRLSFQKLLEVTEIAPVPQHVKEPRTNPYIFFKEEEVPGGWDRDITEYRKRHLR 2v4j A 2.1 BS04 SRM B 1 R83 R101 G134 S135 T136 D138 Y212 K213 K215 K217 R231 K332 A333 I335 R378 R82 R100 G133 S134 T135 D137 Y211 K212 K214 K216 R230 K331 A332 I334 R377 1.8.99.3 0000103,0005515,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45574 18829451 503 AKHATPKLDQLESGPWPSFVSDIKQEAAYRAANPKGLDYQVPVDCPEDLLGVLELSYDEGETHWKHGGIVGVFGYGGGVIGRYCDQPEKFPGVAHFHTVRVAQPSGKYYSADYLRQLCDIWDLRGSGLTNMHGSTGDIVLLGTQTPQLEEIFFELTHNLNTDLGGSGSNLRTPESCLGKSRCEFACYDSQAACYELTMEYQDELHRPAFPYKFKFKFDACPNGCVASIARSDFSVIGTWKDDIKIDAEAVKAYVAGEFKPNAGAHSGRDWGKFDIEAEVVNRCPSKCMKWDGSKLSIDNKECVRCMHCINTMPRALHIGDERGASILCGAKAPILDGAQMGSLLVPFVAAEEPFDEIKEVVEKIWDWWMEEGKNRERLGETMKRLSFQKLLEVTEIAPVPQHVKEPRTNPYIFFKEEEVPGGWDRDITEYRKRHLR 2v4j A 2.1 BS05 SO3 B 1 R101 R172 K213 K215 R100 R171 K212 K214 1.8.99.3 0000103,0005515,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45574 18829451 504 AKHATPKLDQLESGPWPSFVSDIKQEAAYRAANPKGLDYQVPVDCPEDLLGVLELSYDEGETHWKHGGIVGVFGYGGGVIGRYCDQPEKFPGVAHFHTVRVAQPSGKYYSADYLRQLCDIWDLRGSGLTNMHGSTGDIVLLGTQTPQLEEIFFELTHNLNTDLGGSGSNLRTPESCLGKSRCEFACYDSQAACYELTMEYQDELHRPAFPYKFKFKFDACPNGCVASIARSDFSVIGTWKDDIKIDAEAVKAYVAGEFKPNAGAHSGRDWGKFDIEAEVVNRCPSKCMKWDGSKLSIDNKECVRCMHCINTMPRALHIGDERGASILCGAKAPILDGAQMGSLLVPFVAAEEPFDEIKEVVEKIWDWWMEEGKNRERLGETMKRLSFQKLLEVTEIAPVPQHVKEPRTNPYIFFKEEEVPGGWDRDITEYRKRHLR 2v4j B 2.1 BS01 SH0 A 1 H44 H54 R66 R94 T96 T97 R98 N100 G136 S140 R183 V289 S290 R292 R336 H43 H53 R65 R93 T95 T96 R97 N99 G135 S139 R182 V288 S289 R291 R335 1.8.1.22 0000103,0005515,0006790,0009055,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45575 18829451 503 AFISSGYNPEKPMANRITDIGPRKFDEFFPPVIAKNFGSWLYHEILEPGVLMHVAESGDKVYTVRVGAARLMSITHIREMCDIADKYCGGHLRFTTRNNVEFMVADEASLKALKEDLASRKFDGGSLKFPIGGTGAGVSNIVHTQGWVHCHTPATDASGPVKAIMDEVFEDFQSMRLPAPVRISLACCINMCGAVHCSDIGVVGIHRKPPMIDHEWTDQLCEIPLAVASCPTAAVRPTKLEIGDKKVNTIAIKNERCMYCGNCYTMCPALPISDGEGDGVVIMVGGKVSNRISMPKFSKVVVAYIPNEPPRWPSLTKTIKHIIEVYSANAYKYERLGEWAERIGWERFFSLTGLEFSHHLIDDFRDPAYYTWRQSTQFKF 2v4j B 2.1 BS02 SF4 B 1 T145 C151 T153 P154 C188 C189 N191 C193 T144 C150 T152 P153 C187 C188 N190 C192 1.8.1.22 0000103,0005515,0006790,0009055,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45575 18829451 501 AFISSGYNPEKPMANRITDIGPRKFDEFFPPVIAKNFGSWLYHEILEPGVLMHVAESGDKVYTVRVGAARLMSITHIREMCDIADKYCGGHLRFTTRNNVEFMVADEASLKALKEDLASRKFDGGSLKFPIGGTGAGVSNIVHTQGWVHCHTPATDASGPVKAIMDEVFEDFQSMRLPAPVRISLACCINMCGAVHCSDIGVVGIHRKPPMIDHEWTDQLCEIPLAVASCPTAAVRPTKLEIGDKKVNTIAIKNERCMYCGNCYTMCPALPISDGEGDGVVIMVGGKVSNRISMPKFSKVVVAYIPNEPPRWPSLTKTIKHIIEVYSANAYKYERLGEWAERIGWERFFSLTGLEFSHHLIDDFRDPAYYTWRQSTQFKF 2v4j B 2.1 BS03 SF4 B 2 P211 C231 V236 I253 C258 M259 Y260 C261 G262 C264 P210 C230 V235 I252 C257 M258 Y259 C260 G261 C263 1.8.1.22 0000103,0005515,0006790,0009055,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45575 18829451 502 AFISSGYNPEKPMANRITDIGPRKFDEFFPPVIAKNFGSWLYHEILEPGVLMHVAESGDKVYTVRVGAARLMSITHIREMCDIADKYCGGHLRFTTRNNVEFMVADEASLKALKEDLASRKFDGGSLKFPIGGTGAGVSNIVHTQGWVHCHTPATDASGPVKAIMDEVFEDFQSMRLPAPVRISLACCINMCGAVHCSDIGVVGIHRKPPMIDHEWTDQLCEIPLAVASCPTAAVRPTKLEIGDKKVNTIAIKNERCMYCGNCYTMCPALPISDGEGDGVVIMVGGKVSNRISMPKFSKVVVAYIPNEPPRWPSLTKTIKHIIEVYSANAYKYERLGEWAERIGWERFFSLTGLEFSHHLIDDFRDPAYYTWRQSTQFKF 2v4j B 2.1 BS04 SRM B 1 R71 T145 Q146 H150 H152 N191 C193 G194 R70 T144 Q145 H149 H151 N190 C192 G193 1.8.1.22 0000103,0005515,0006790,0009055,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45575 18829451 503 AFISSGYNPEKPMANRITDIGPRKFDEFFPPVIAKNFGSWLYHEILEPGVLMHVAESGDKVYTVRVGAARLMSITHIREMCDIADKYCGGHLRFTTRNNVEFMVADEASLKALKEDLASRKFDGGSLKFPIGGTGAGVSNIVHTQGWVHCHTPATDASGPVKAIMDEVFEDFQSMRLPAPVRISLACCINMCGAVHCSDIGVVGIHRKPPMIDHEWTDQLCEIPLAVASCPTAAVRPTKLEIGDKKVNTIAIKNERCMYCGNCYTMCPALPISDGEGDGVVIMVGGKVSNRISMPKFSKVVVAYIPNEPPRWPSLTKTIKHIIEVYSANAYKYERLGEWAERIGWERFFSLTGLEFSHHLIDDFRDPAYYTWRQSTQFKF 2v4j D 2.1 BS01 SF4 D 1 C177 C183 F185 A186 A220 C221 N223 C225 C176 C182 F184 A185 A219 C220 N222 C224 1.8.99.3 0000103,0005515,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45574 18829451 501 AKHATPKLDQLESGPWPSFVSDIKQEAAYRAANPKGLDYQVPVDCPEDLLGVLELSYDEGETHWKHGGIVGVFGYGGGVIGRYCDQPEKFPGVAHFHTVRVAQPSGKYYSADYLRQLCDIWDLRGSGLTNMHGSTGDIVLLGTQTPQLEEIFFELTHNLNTDLGGSGSNLRTPESCLGKSRCEFACYDSQAACYELTMEYQDELHRPAFPYKFKFKFDACPNGCVASIARSDFSVIGTWKDDIKIDAEAVKAYVAGEFKPNAGAHSGRDWGKFDIEAEVVNRCPSKCMKWDGSKLSIDNKECVRCMHCINTMPRALHIGDERGASILCGAKAPILDGAQMGSLLVPFVAAEEPFDEIKEVVEKIWDWWMEEGKNRERLGETMKRLSFQKLLEVTEIAPVPQHVKEPRTNPYIFFKEEEVPGGWDRDITEYRKRHLR 2v4j D 2.1 BS02 SF4 D 2 I244 C284 P285 C288 M289 C303 V304 R305 C306 M307 C309 I243 C283 P284 C287 M288 C302 V303 R304 C305 M306 C308 1.8.99.3 0000103,0005515,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45574 18829451 502 AKHATPKLDQLESGPWPSFVSDIKQEAAYRAANPKGLDYQVPVDCPEDLLGVLELSYDEGETHWKHGGIVGVFGYGGGVIGRYCDQPEKFPGVAHFHTVRVAQPSGKYYSADYLRQLCDIWDLRGSGLTNMHGSTGDIVLLGTQTPQLEEIFFELTHNLNTDLGGSGSNLRTPESCLGKSRCEFACYDSQAACYELTMEYQDELHRPAFPYKFKFKFDACPNGCVASIARSDFSVIGTWKDDIKIDAEAVKAYVAGEFKPNAGAHSGRDWGKFDIEAEVVNRCPSKCMKWDGSKLSIDNKECVRCMHCINTMPRALHIGDERGASILCGAKAPILDGAQMGSLLVPFVAAEEPFDEIKEVVEKIWDWWMEEGKNRERLGETMKRLSFQKLLEVTEIAPVPQHVKEPRTNPYIFFKEEEVPGGWDRDITEYRKRHLR 2v4j D 2.1 BS03 SH0 D 1 C177 L178 C183 E184 G224 C225 N262 N311 C176 L177 C182 E183 G223 C224 N261 N310 1.8.99.3 0000103,0005515,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45574 18829451 503 AKHATPKLDQLESGPWPSFVSDIKQEAAYRAANPKGLDYQVPVDCPEDLLGVLELSYDEGETHWKHGGIVGVFGYGGGVIGRYCDQPEKFPGVAHFHTVRVAQPSGKYYSADYLRQLCDIWDLRGSGLTNMHGSTGDIVLLGTQTPQLEEIFFELTHNLNTDLGGSGSNLRTPESCLGKSRCEFACYDSQAACYELTMEYQDELHRPAFPYKFKFKFDACPNGCVASIARSDFSVIGTWKDDIKIDAEAVKAYVAGEFKPNAGAHSGRDWGKFDIEAEVVNRCPSKCMKWDGSKLSIDNKECVRCMHCINTMPRALHIGDERGASILCGAKAPILDGAQMGSLLVPFVAAEEPFDEIKEVVEKIWDWWMEEGKNRERLGETMKRLSFQKLLEVTEIAPVPQHVKEPRTNPYIFFKEEEVPGGWDRDITEYRKRHLR 2v4j D 2.1 BS04 SRM E 1 I81 R83 R101 G134 S135 T136 D138 Y212 K213 K215 K217 R231 A333 I335 R376 R378 I80 R82 R100 G133 S134 T135 D137 Y211 K212 K214 K216 R230 A332 I334 R375 R377 1.8.99.3 0000103,0005515,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45574 18829451 503 AKHATPKLDQLESGPWPSFVSDIKQEAAYRAANPKGLDYQVPVDCPEDLLGVLELSYDEGETHWKHGGIVGVFGYGGGVIGRYCDQPEKFPGVAHFHTVRVAQPSGKYYSADYLRQLCDIWDLRGSGLTNMHGSTGDIVLLGTQTPQLEEIFFELTHNLNTDLGGSGSNLRTPESCLGKSRCEFACYDSQAACYELTMEYQDELHRPAFPYKFKFKFDACPNGCVASIARSDFSVIGTWKDDIKIDAEAVKAYVAGEFKPNAGAHSGRDWGKFDIEAEVVNRCPSKCMKWDGSKLSIDNKECVRCMHCINTMPRALHIGDERGASILCGAKAPILDGAQMGSLLVPFVAAEEPFDEIKEVVEKIWDWWMEEGKNRERLGETMKRLSFQKLLEVTEIAPVPQHVKEPRTNPYIFFKEEEVPGGWDRDITEYRKRHLR 2v4j D 2.1 BS05 SO3 E 1 R101 R172 K213 R100 R171 K212 1.8.99.3 0000103,0005515,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45574 18829451 504 AKHATPKLDQLESGPWPSFVSDIKQEAAYRAANPKGLDYQVPVDCPEDLLGVLELSYDEGETHWKHGGIVGVFGYGGGVIGRYCDQPEKFPGVAHFHTVRVAQPSGKYYSADYLRQLCDIWDLRGSGLTNMHGSTGDIVLLGTQTPQLEEIFFELTHNLNTDLGGSGSNLRTPESCLGKSRCEFACYDSQAACYELTMEYQDELHRPAFPYKFKFKFDACPNGCVASIARSDFSVIGTWKDDIKIDAEAVKAYVAGEFKPNAGAHSGRDWGKFDIEAEVVNRCPSKCMKWDGSKLSIDNKECVRCMHCINTMPRALHIGDERGASILCGAKAPILDGAQMGSLLVPFVAAEEPFDEIKEVVEKIWDWWMEEGKNRERLGETMKRLSFQKLLEVTEIAPVPQHVKEPRTNPYIFFKEEEVPGGWDRDITEYRKRHLR 2v4j E 2.1 BS01 SH0 D 1 H44 H54 R66 R94 T96 T97 R98 N100 T135 G136 S140 R183 V289 S290 R292 R336 H43 H53 R65 R93 T95 T96 R97 N99 T134 G135 S139 R182 V288 S289 R291 R335 1.8.1.22 0000103,0005515,0006790,0009055,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45575 18829451 503 AFISSGYNPEKPMANRITDIGPRKFDEFFPPVIAKNFGSWLYHEILEPGVLMHVAESGDKVYTVRVGAARLMSITHIREMCDIADKYCGGHLRFTTRNNVEFMVADEASLKALKEDLASRKFDGGSLKFPIGGTGAGVSNIVHTQGWVHCHTPATDASGPVKAIMDEVFEDFQSMRLPAPVRISLACCINMCGAVHCSDIGVVGIHRKPPMIDHEWTDQLCEIPLAVASCPTAAVRPTKLEIGDKKVNTIAIKNERCMYCGNCYTMCPALPISDGEGDGVVIMVGGKVSNRISMPKFSKVVVAYIPNEPPRWPSLTKTIKHIIEVYSANAYKYERLGEWAERIGWERFFSLTGLEFSHHLIDDFRDPAYYTWRQSTQFKF 2v4j E 2.1 BS02 SF4 E 1 T145 Q146 C151 T153 P154 C188 C189 N191 C193 T144 Q145 C150 T152 P153 C187 C188 N190 C192 1.8.1.22 0000103,0005515,0006790,0009055,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45575 18829451 501 AFISSGYNPEKPMANRITDIGPRKFDEFFPPVIAKNFGSWLYHEILEPGVLMHVAESGDKVYTVRVGAARLMSITHIREMCDIADKYCGGHLRFTTRNNVEFMVADEASLKALKEDLASRKFDGGSLKFPIGGTGAGVSNIVHTQGWVHCHTPATDASGPVKAIMDEVFEDFQSMRLPAPVRISLACCINMCGAVHCSDIGVVGIHRKPPMIDHEWTDQLCEIPLAVASCPTAAVRPTKLEIGDKKVNTIAIKNERCMYCGNCYTMCPALPISDGEGDGVVIMVGGKVSNRISMPKFSKVVVAYIPNEPPRWPSLTKTIKHIIEVYSANAYKYERLGEWAERIGWERFFSLTGLEFSHHLIDDFRDPAYYTWRQSTQFKF 2v4j E 2.1 BS03 SF4 E 2 P211 C231 V236 I253 C258 M259 Y260 C261 G262 C264 P210 C230 V235 I252 C257 M258 Y259 C260 G261 C263 1.8.1.22 0000103,0005515,0006790,0009055,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45575 18829451 502 AFISSGYNPEKPMANRITDIGPRKFDEFFPPVIAKNFGSWLYHEILEPGVLMHVAESGDKVYTVRVGAARLMSITHIREMCDIADKYCGGHLRFTTRNNVEFMVADEASLKALKEDLASRKFDGGSLKFPIGGTGAGVSNIVHTQGWVHCHTPATDASGPVKAIMDEVFEDFQSMRLPAPVRISLACCINMCGAVHCSDIGVVGIHRKPPMIDHEWTDQLCEIPLAVASCPTAAVRPTKLEIGDKKVNTIAIKNERCMYCGNCYTMCPALPISDGEGDGVVIMVGGKVSNRISMPKFSKVVVAYIPNEPPRWPSLTKTIKHIIEVYSANAYKYERLGEWAERIGWERFFSLTGLEFSHHLIDDFRDPAYYTWRQSTQFKF 2v4j E 2.1 BS04 SRM E 1 R71 T145 Q146 H150 H152 N191 C193 G194 R70 T144 Q145 H149 H151 N190 C192 G193 1.8.1.22 0000103,0005515,0006790,0009055,0009337,0016002,0016491,0018551,0020037,0046872,0050311,0051536,0051539 P45575 18829451 503 AFISSGYNPEKPMANRITDIGPRKFDEFFPPVIAKNFGSWLYHEILEPGVLMHVAESGDKVYTVRVGAARLMSITHIREMCDIADKYCGGHLRFTTRNNVEFMVADEASLKALKEDLASRKFDGGSLKFPIGGTGAGVSNIVHTQGWVHCHTPATDASGPVKAIMDEVFEDFQSMRLPAPVRISLACCINMCGAVHCSDIGVVGIHRKPPMIDHEWTDQLCEIPLAVASCPTAAVRPTKLEIGDKKVNTIAIKNERCMYCGNCYTMCPALPISDGEGDGVVIMVGGKVSNRISMPKFSKVVVAYIPNEPPRWPSLTKTIKHIIEVYSANAYKYERLGEWAERIGWERFFSLTGLEFSHHLIDDFRDPAYYTWRQSTQFKF