2rk7 A 1.9 BS01 MN A 1 K244 H264 D311 K241 H261 D308 R87 Y235 K244 H264 S286 C288 D311 R405 R84 Y232 K241 H261 S283 C285 D308 R402 2.7.11.-,4.1.1.32 0000287,0004550,0004611,0004613,0005525,0005737,0005783,0005829,0006006,0006094,0006107,0006629,0009617,0014823,0016301,0016310,0016831,0017076,0018105,0019003,0019543,0030145,0031406,0031667,0032496,0032868,0032869,0033993,0042593,0042594,0043382,0043648,0045944,0046166,0046327,0046872,0046889,0046890,0051365,0070365,0070741,0071300,0071320,0071332,0071333,0071347,0071356,0071377,0071456,0071474,0071475,0071476,0071477,0071549,0072350,0097403,0106264,1904628,1904640 P07379 18197707 700 QLHNGLDFSAKVIQGSLDSLPQEVRKFVEGNAQLCQPEYIHICDGSEEEYGRLLAHMQEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRDTVPIPKSGQSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLAKIGIELTDSPYVVASMRIMTRMGTSVLEALGDGEFIKCLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRIASRLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPTLPGWKVECVGDDIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDEEPCAHPNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEAVIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKLPKIFHVNWFRKDKNGKFLWPGFGENSRVLEWMFGRIEGEDSAKLTPIGYVPKEDALNLKGLGDVNVEELFGISKEFWEKEVEEIDKYLEDQVNADLPYEIERELRALKQRISQM 2rk7 A 1.9 BS02 OXL A 1 R87 K244 H264 D311 R405 R84 K241 H261 D308 R402 R87 Y235 K244 H264 S286 C288 D311 R405 R84 Y232 K241 H261 S283 C285 D308 R402 2.7.11.-,4.1.1.32 0000287,0004550,0004611,0004613,0005525,0005737,0005783,0005829,0006006,0006094,0006107,0006629,0009617,0014823,0016301,0016310,0016831,0017076,0018105,0019003,0019543,0030145,0031406,0031667,0032496,0032868,0032869,0033993,0042593,0042594,0043382,0043648,0045944,0046166,0046327,0046872,0046889,0046890,0051365,0070365,0070741,0071300,0071320,0071332,0071333,0071347,0071356,0071377,0071456,0071474,0071475,0071476,0071477,0071549,0072350,0097403,0106264,1904628,1904640 Ki=89uM P07379 18197707 5575 QLHNGLDFSAKVIQGSLDSLPQEVRKFVEGNAQLCQPEYIHICDGSEEEYGRLLAHMQEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRDTVPIPKSGQSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLAKIGIELTDSPYVVASMRIMTRMGTSVLEALGDGEFIKCLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRIASRLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPTLPGWKVECVGDDIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDEEPCAHPNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEAVIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKLPKIFHVNWFRKDKNGKFLWPGFGENSRVLEWMFGRIEGEDSAKLTPIGYVPKEDALNLKGLGDVNVEELFGISKEFWEKEVEEIDKYLEDQVNADLPYEIERELRALKQRISQM 2rk7 B 1.9 BS01 MN B 1 K244 H264 D311 K241 H261 D308 R87 Y235 K244 H264 S286 C288 D311 R405 R84 Y232 K241 H261 S283 C285 D308 R402 2.7.11.-,4.1.1.32 0000287,0004550,0004611,0004613,0005525,0005737,0005783,0005829,0006006,0006094,0006107,0006629,0009617,0014823,0016301,0016310,0016831,0017076,0018105,0019003,0019543,0030145,0031406,0031667,0032496,0032868,0032869,0033993,0042593,0042594,0043382,0043648,0045944,0046166,0046327,0046872,0046889,0046890,0051365,0070365,0070741,0071300,0071320,0071332,0071333,0071347,0071356,0071377,0071456,0071474,0071475,0071476,0071477,0071549,0072350,0097403,0106264,1904628,1904640 P07379 18197707 700 QLHNGLDFSAKVIQGSLDSLPQEVRKFVEGNAQLCQPEYIHICDGSEEEYGRLLAHMQEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRDTVPIPKSGQSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLAKIGIELTDSPYVVASMRIMTRMGTSVLEALGDGEFIKCLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRIASRLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPTLPGWKVECVGDDIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDEEPCAHPNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATGKVIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKLPKIFHVNWFRKDKNGKFLWPGFGENSRVLEWMFGRIEGEDSAKLTPIGYVPKEDALNLKGLGDVNVEELFGISKEFWEKEVEEIDKYLEDQVNADLPYEIERELRALKQRISQM 2rk7 B 1.9 BS02 OXL B 1 K244 H264 S286 D311 R405 K241 H261 S283 D308 R402 R87 Y235 K244 H264 S286 C288 D311 R405 R84 Y232 K241 H261 S283 C285 D308 R402 2.7.11.-,4.1.1.32 0000287,0004550,0004611,0004613,0005525,0005737,0005783,0005829,0006006,0006094,0006107,0006629,0009617,0014823,0016301,0016310,0016831,0017076,0018105,0019003,0019543,0030145,0031406,0031667,0032496,0032868,0032869,0033993,0042593,0042594,0043382,0043648,0045944,0046166,0046327,0046872,0046889,0046890,0051365,0070365,0070741,0071300,0071320,0071332,0071333,0071347,0071356,0071377,0071456,0071474,0071475,0071476,0071477,0071549,0072350,0097403,0106264,1904628,1904640 Ki=89uM P07379 18197707 5575 QLHNGLDFSAKVIQGSLDSLPQEVRKFVEGNAQLCQPEYIHICDGSEEEYGRLLAHMQEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRDTVPIPKSGQSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLAKIGIELTDSPYVVASMRIMTRMGTSVLEALGDGEFIKCLHSVGCPLPLKKPLVNNWACNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRIASRLAKEEGWLAEHMLILGITNPEGKKKYLAAAFPSACGKTNLAMMNPTLPGWKVECVGDDIAWMKFDAQGNLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWRPQDEEPCAHPNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATGKVIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKLPKIFHVNWFRKDKNGKFLWPGFGENSRVLEWMFGRIEGEDSAKLTPIGYVPKEDALNLKGLGDVNVEELFGISKEFWEKEVEEIDKYLEDQVNADLPYEIERELRALKQRISQM