2r9s A 2.4 BS01 255 A 1 I70 G71 N89 A91 M146 L148 M149 D150 A151 N152 V196 L206 I25 G26 N44 A46 M101 L103 M104 D105 A106 N107 V151 L161 D189 K191 N194 D207 D144 K146 N149 D162 2.7.11.24 0004672,0004707,0005524,0006468 ic50=0.15uM -logKd/Ki=6.82, IC50=0.15uM IC50=150nM P53779 17911023 502 NQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDKQLDEREHTIEEWKELIYKEVMNS 2r9s A 2.4 BS02 TFA A 1 G71 S72 S193 L206 G26 S27 S148 L161 D189 K191 N194 D207 D144 K146 N149 D162 2.7.11.24 0004672,0004707,0005524,0006468 P53779 17911023 601 NQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDKQLDEREHTIEEWKELIYKEVMNS 2r9s B 2.4 BS01 255 B 1 K68 I70 G71 N89 A91 E147 L148 M149 D150 A151 N152 Q155 V196 L206 K23 I25 G26 N44 A46 E102 L103 M104 D105 A106 N107 Q110 V151 L161 D189 K191 N194 D207 D144 K146 N149 D162 2.7.11.24 0004672,0004707,0005524,0006468 ic50=0.15uM IC50=150nM P53779 17911023 501 NQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDKQLDEREHTIEEWKELIYKEVMNS 2r9s B 2.4 BS02 TFA B 1 I70 G71 S72 L206 I25 G26 S27 L161 D189 K191 N194 D207 D144 K146 N149 D162 2.7.11.24 0004672,0004707,0005524,0006468 P53779 17911023 602 NQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDKQLDEREHTIEEWKELIYKEVMNS