2q8m A 2.05 BS01 BG6 A 1 Y210 I221 K222 Q225 Y188 I199 K200 Q203 E89 E90 D110 L112 D113 E275 E67 E68 D88 L90 D91 E253 3.1.3.11 0000166,0000287,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0030388,0032991,0042132,0042578,0042802,0046872 Ki~700uM P0A993 17567577 340 MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVEDVERFIREFPDA 2q8m A 2.05 BS02 FBP A 1 D110 D113 G114 N206 Y239 L243 Y257 Y259 K269 E275 D88 D91 G92 N184 Y217 L221 Y235 Y237 K247 E253 E89 E90 D110 L112 D113 E275 E67 E68 D88 L90 D91 E253 3.1.3.11 0000166,0000287,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0030388,0032991,0042132,0042578,0042802,0046872 ic50=6uM P0A993 17567577 344 MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVEDVERFIREFPDA 2q8m A 2.05 BS03 MG A 1 E89 D110 L112 E67 D88 L90 E89 E90 D110 L112 D113 E275 E67 E68 D88 L90 D91 E253 3.1.3.11 0000166,0000287,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0030388,0032991,0042132,0042578,0042802,0046872 P0A993 17567577 347 MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVEDVERFIREFPDA 2q8m A 2.05 BS04 MG A 2 D110 D113 E275 D88 D91 E253 E89 E90 D110 L112 D113 E275 E67 E68 D88 L90 D91 E253 3.1.3.11 0000166,0000287,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0030388,0032991,0042132,0042578,0042802,0046872 P0A993 17567577 348 MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVEDVERFIREFPDA 2q8m A 2.05 BS05 AMP A 1 I8 Q12 F15 A18 T19 G20 E21 L22 K104 Y105 I8 Q12 F15 A18 T19 G20 E21 L22 K82 Y83 E89 E90 D110 L112 D113 E275 E67 E68 D88 L90 D91 E253 3.1.3.11 0000166,0000287,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0030388,0032991,0042132,0042578,0042802,0046872 Ki=94uM -logKd/Ki=4.03, Ki=94uM P0A993 17567577 341 MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVEDVERFIREFPDA 2q8m B 2.05 BS01 FBP B 1 D110 D113 G114 N206 Y239 L243 Y257 Y259 K269 E275 D88 D91 G92 N184 Y217 L221 Y235 Y237 K247 E253 E89 E90 D110 L112 D113 E275 E67 E68 D88 L90 D91 E253 3.1.3.11 0000166,0000287,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0030388,0032991,0042132,0042578,0042802,0046872 ic50=6uM P0A993 17567577 342 MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVEDVERFIREFPDA 2q8m B 2.05 BS02 MG B 1 E89 D110 L112 E67 D88 L90 E89 E90 D110 L112 D113 E275 E67 E68 D88 L90 D91 E253 3.1.3.11 0000166,0000287,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0030388,0032991,0042132,0042578,0042802,0046872 P0A993 17567577 345 MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVEDVERFIREFPDA 2q8m B 2.05 BS03 MG B 2 D110 D113 E275 D88 D91 E253 E89 E90 D110 L112 D113 E275 E67 E68 D88 L90 D91 E253 3.1.3.11 0000166,0000287,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0030388,0032991,0042132,0042578,0042802,0046872 P0A993 17567577 346 MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVEDVERFIREFPDA 2q8m B 2.05 BS04 AMP B 1 I8 Q12 F15 A18 T19 G20 E21 L22 K104 Y105 I8 Q12 F15 A18 T19 G20 E21 L22 K82 Y83 E89 E90 D110 L112 D113 E275 E67 E68 D88 L90 D91 E253 3.1.3.11 0000166,0000287,0005737,0005829,0005975,0005986,0006000,0006002,0006094,0016787,0016791,0030388,0032991,0042132,0042578,0042802,0046872 Ki=94uM P0A993 17567577 343 MKTLGEFIVEKQHEFSHATGELTALLSAIKLGAKIIHRDINKAGLFANEKLKAALKARDIVAGIASEEEDEIVVFEGCEHAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVTPVGTPVTEEDFLQPGNKQVAAGYVVYGSSTMLVYTTGCGVHAFTYDPSLGVFCLCQERMRFPEKGKTYSINEGNYIKFPNGVKKYIKFCQEEDKSTNRPYTSRYIGSLVADFHRNLLKGGIYLYPSTASHPDGKLRLLYECNPMAFLAEQAGGKASDGKERILDIIPETLHQRRSFFVGNDHMVEDVERFIREFPDA