2q80 A 2.7 BS01 MG A 1 D64 D68 D59 D63 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 O95749 16698791 400 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFK 2q80 A 2.7 BS02 MG A 2 D64 D68 D59 D63 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 O95749 16698791 401 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFK 2q80 A 2.7 BS03 GRG A 1 L31 S32 D64 R73 Q126 K151 T152 L155 F156 A159 K202 L26 S27 D59 R68 Q121 K146 T147 L150 F151 A154 K191 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 -logKd/Ki=4.60, Ki=25uM O95749 16698791 500 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFK 2q80 B 2.7 BS01 MG B 1 D64 D68 D59 D63 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 O95749 16698791 400 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 2q80 B 2.7 BS02 MG B 2 D64 D68 D59 D63 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 O95749 16698791 401 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 2q80 B 2.7 BS03 GRG B 1 L31 T53 D64 R73 Q126 K151 L155 A159 K212 L26 T48 D59 R68 Q121 K146 L150 A154 K201 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 -logKd/Ki=4.60, Ki=25uM O95749 16698791 500 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 2q80 C 2.7 BS01 MG C 1 D64 D68 D59 D63 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 O95749 16698791 400 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 2q80 C 2.7 BS02 MG C 2 D64 D68 D59 D63 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 O95749 16698791 401 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 2q80 C 2.7 BS03 GRG C 1 S32 T53 D64 R73 Q126 K151 T152 F156 A159 D188 S27 T48 D59 R68 Q121 K146 T147 F151 A154 D183 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 O95749 16698791 500 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 2q80 D 2.7 BS01 MG D 1 D64 D68 D59 D63 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 O95749 16698791 400 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSNKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 2q80 D 2.7 BS02 MG D 2 D64 D68 D59 D63 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 O95749 16698791 401 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSNKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 2q80 D 2.7 BS03 GRG D 1 S32 H57 D64 D68 R73 Q126 K151 F156 A159 D188 K202 K212 S27 H52 D59 D63 R68 Q121 K146 F151 A154 D183 K192 K202 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 O95749 16698791 500 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSNKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 2q80 E 2.7 BS01 MG E 1 D64 D68 D59 D63 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 O95749 16698791 400 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 2q80 E 2.7 BS02 MG E 2 D64 D68 D59 D63 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 O95749 16698791 401 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 2q80 E 2.7 BS03 GRG E 1 L31 S32 F35 T53 H57 D64 R73 K151 F156 A159 D188 K202 L26 S27 F30 T48 H52 D59 R68 K146 F151 A154 D183 K191 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 O95749 16698791 500 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 2q80 F 2.7 BS01 MG F 1 D64 D68 D59 D63 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 O95749 16698791 400 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 2q80 F 2.7 BS02 MG F 2 D64 D68 D59 D63 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 O95749 16698791 401 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF 2q80 F 2.7 BS03 GRG F 1 D64 R73 Q126 L155 K202 D59 R68 Q121 L150 K191 2.5.1.-,2.5.1.1,2.5.1.10,2.5.1.29 0004161,0004311,0004337,0004659,0005515,0005654,0005737,0005829,0006720,0008299,0016740,0030018,0033384,0033386,0042802,0045337,0046872,0048471 O95749 16698791 500 ETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMF