2pll A 1.9 BS01 MN A 1 D124 H126 D232 D234 D120 H122 D228 D230 H101 D124 H126 D128 H141 D232 D234 E277 H97 D120 H122 D124 H137 D228 D230 E273 3.5.3.1 0000050,0002250,0004053,0005515,0005576,0005615,0005634,0005737,0005829,0006525,0006527,0009624,0016787,0016813,0019547,0030145,0035578,0035580,0042130,0042832,0045087,0046007,0046872,0060336,0070965,2000552 P05089 17562323 463 SRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL 2pll A 1.9 BS02 MN A 2 H101 D124 D128 D232 H97 D120 D124 D228 H101 D124 H126 D128 H141 D232 D234 E277 H97 D120 H122 D124 H137 D228 D230 E273 3.5.3.1 0000050,0002250,0004053,0005515,0005576,0005615,0005634,0005737,0005829,0006525,0006527,0009624,0016787,0016813,0019547,0030145,0035578,0035580,0042130,0042832,0045087,0046007,0046872,0060336,0070965,2000552 P05089 17562323 464 SRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL 2pll A 1.9 BS03 ABH A 1 D124 D128 S137 H141 G142 D183 D232 E277 D120 D124 S133 H137 G138 D179 D228 E273 H101 D124 H126 D128 H141 D232 D234 E277 H97 D120 H122 D124 H137 D228 D230 E273 3.5.3.1 0000050,0002250,0004053,0005515,0005576,0005615,0005634,0005737,0005829,0006525,0006527,0009624,0016787,0016813,0019547,0030145,0035578,0035580,0042130,0042832,0045087,0046007,0046872,0060336,0070965,2000552 Kd=5nM -logKd/Ki=8.30, Kd=5nM P05089 17562323 555 SRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL 2pll B 1.9 BS01 MN B 1 D124 H126 D232 D234 D120 H122 D228 D230 H101 D124 H126 D128 H141 D232 D234 E277 H97 D120 H122 D124 H137 D228 D230 E273 3.5.3.1 0000050,0002250,0004053,0005515,0005576,0005615,0005634,0005737,0005829,0006525,0006527,0009624,0016787,0016813,0019547,0030145,0035578,0035580,0042130,0042832,0045087,0046007,0046872,0060336,0070965,2000552 P05089 17562323 461 SRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL 2pll B 1.9 BS02 MN B 2 H101 D124 D128 D232 H97 D120 D124 D228 H101 D124 H126 D128 H141 D232 D234 E277 H97 D120 H122 D124 H137 D228 D230 E273 3.5.3.1 0000050,0002250,0004053,0005515,0005576,0005615,0005634,0005737,0005829,0006525,0006527,0009624,0016787,0016813,0019547,0030145,0035578,0035580,0042130,0042832,0045087,0046007,0046872,0060336,0070965,2000552 P05089 17562323 462 SRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL 2pll B 1.9 BS03 ABH B 1 H126 D128 N130 S137 H141 D183 D232 H122 D124 N126 S133 H137 D179 D228 H101 D124 H126 D128 H141 D232 D234 E277 H97 D120 H122 D124 H137 D228 D230 E273 3.5.3.1 0000050,0002250,0004053,0005515,0005576,0005615,0005634,0005737,0005829,0006525,0006527,0009624,0016787,0016813,0019547,0030145,0035578,0035580,0042130,0042832,0045087,0046007,0046872,0060336,0070965,2000552 Kd=5nM P05089 17562323 556 SRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYL