2pjc A 1.74 BS01 ZN A 1 H69 E72 H196 H64 E67 H192 H69 E72 R127 H196 E270 H64 E67 R122 H192 E266 3.4.17.2 0004181,0006508,0008270 P09955 18219114 400 GHSYEKYNNWETIEAWTKQVTSENPDLISRTAIGTTFLGNNIYLLKVGKPGPNKPAIFMDCGFHAREWISHAFCQWFVREAVLTYGYESHMTEFLNKLDFYVLPVLNIDGYIYTWTKNRMWRKTRSTNAGTTCIGTDPNRNFDAGWCTTGASTDPCDETYCGSAAESEKETKALADFIRNNLSSIKAYLTIHSYSQMILYPYSYDYKLPENNAELNNLAKAAVKELATLYGTKYTYGPGATTIYPAAGGSDDWAYDQGIKYSFTFELRDKGRYGFILPESQIQATCEETMLAIKYVTNYVLGHL 2pjc A 1.74 BS02 343 A 1 H69 E72 R127 N144 R145 T164 H196 S197 Y198 S199 L203 S207 I247 Y248 A250 D255 E270 F279 H64 E67 R122 N139 R140 T159 H192 S193 Y194 S195 L199 S203 I243 Y244 A246 D251 E266 F275 H69 E72 R127 H196 E270 H64 E67 R122 H192 E266 3.4.17.2 0004181,0006508,0008270 ic50=1.9nM -logKd/Ki=8.72, IC50=1.9nM P09955 18219114 401 GHSYEKYNNWETIEAWTKQVTSENPDLISRTAIGTTFLGNNIYLLKVGKPGPNKPAIFMDCGFHAREWISHAFCQWFVREAVLTYGYESHMTEFLNKLDFYVLPVLNIDGYIYTWTKNRMWRKTRSTNAGTTCIGTDPNRNFDAGWCTTGASTDPCDETYCGSAAESEKETKALADFIRNNLSSIKAYLTIHSYSQMILYPYSYDYKLPENNAELNNLAKAAVKELATLYGTKYTYGPGATTIYPAAGGSDDWAYDQGIKYSFTFELRDKGRYGFILPESQIQATCEETMLAIKYVTNYVLGHL 2pjc B 1.74 BS01 ZN B 1 H69 E72 H196 H64 E67 H192 H69 E72 R127 H196 E270 H64 E67 R122 H192 E266 3.4.17.2 0004181,0006508,0008270 P09955 18219114 500 GHSYEKYNNWETIEAWTKQVTSENPDLISRTAIGTTFLGNNIYLLKVGKPGPNKPAIFMDCGFHAREWISHAFCQWFVREAVLTYGYESHMTEFLNKLDFYVLPVLNIDGYIYTWTKNRMWRKTRSTNAGTTCIGTDPNRNFDAGWCTTGASTDPCDETYCGSAAESEKETKALADFIRNNLSSIKAYLTIHSYSQMILYPYSYDYKLPENNAELNNLAKAAVKELATLYGTKYTYGPGATTIYPAAGGSDDWAYDQGIKYSFTFELRDKGRYGFILPESQIQATCEETMLAIKYVTNYVLGHL 2pjc B 1.74 BS02 343 B 1 H69 E72 R127 N144 R145 T164 H196 S197 Y198 S199 L203 S207 I247 Y248 A250 D255 E270 H64 E67 R122 N139 R140 T159 H192 S193 Y194 S195 L199 S203 I243 Y244 A246 D251 E266 H69 E72 R127 H196 E270 H64 E67 R122 H192 E266 3.4.17.2 0004181,0006508,0008270 ic50=1.9nM P09955 18219114 501 GHSYEKYNNWETIEAWTKQVTSENPDLISRTAIGTTFLGNNIYLLKVGKPGPNKPAIFMDCGFHAREWISHAFCQWFVREAVLTYGYESHMTEFLNKLDFYVLPVLNIDGYIYTWTKNRMWRKTRSTNAGTTCIGTDPNRNFDAGWCTTGASTDPCDETYCGSAAESEKETKALADFIRNNLSSIKAYLTIHSYSQMILYPYSYDYKLPENNAELNNLAKAAVKELATLYGTKYTYGPGATTIYPAAGGSDDWAYDQGIKYSFTFELRDKGRYGFILPESQIQATCEETMLAIKYVTNYVLGHL 2pjc C 1.74 BS01 ZN C 1 H69 E72 H196 H64 E67 H192 H69 E72 R127 H196 E270 H64 E67 R122 H192 E266 3.4.17.2 0004181,0006508,0008270 P09955 18219114 600 GHSYEKYNNWETIEAWTKQVTSENPDLISRTAIGTTFLGNNIYLLKVGKPGPNKPAIFMDCGFHAREWISHAFCQWFVREAVLTYGYESHMTEFLNKLDFYVLPVLNIDGYIYTWTKNRMWRKTRSTNAGTTCIGTDPNRNFDAGWCTTGASTDPCDETYCGSAAESEKETKALADFIRNNLSSIKAYLTIHSYSQMILYPYSYDYKLPENNAELNNLAKAAVKELATLYGTKYTYGPGATTIYPAAGGSDDWAYDQGIKYSFTFELRDKGRYGFILPESQIQATCEETMLAIKYVTNYVLGHL 2pjc C 1.74 BS02 343 C 1 H69 E72 R127 N144 R145 T164 H196 S197 Y198 S199 L203 S207 I247 Y248 A250 D255 E270 H64 E67 R122 N139 R140 T159 H192 S193 Y194 S195 L199 S203 I243 Y244 A246 D251 E266 H69 E72 R127 H196 E270 H64 E67 R122 H192 E266 3.4.17.2 0004181,0006508,0008270 ic50=1.9nM P09955 18219114 601 GHSYEKYNNWETIEAWTKQVTSENPDLISRTAIGTTFLGNNIYLLKVGKPGPNKPAIFMDCGFHAREWISHAFCQWFVREAVLTYGYESHMTEFLNKLDFYVLPVLNIDGYIYTWTKNRMWRKTRSTNAGTTCIGTDPNRNFDAGWCTTGASTDPCDETYCGSAAESEKETKALADFIRNNLSSIKAYLTIHSYSQMILYPYSYDYKLPENNAELNNLAKAAVKELATLYGTKYTYGPGATTIYPAAGGSDDWAYDQGIKYSFTFELRDKGRYGFILPESQIQATCEETMLAIKYVTNYVLGHL