2ovx A 2.0 BS01 ZN A 1 H401 H405 H411 H117 H121 H127 H401 Q402 H405 H411 H117 Q118 H121 H127 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 17599356 444 FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY 2ovx A 2.0 BS02 ZN A 2 H175 D177 H190 H203 H66 D68 H81 H94 H401 Q402 H405 H411 H117 Q118 H121 H127 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 17599356 445 FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY 2ovx A 2.0 BS03 CA A 1 D182 G183 D185 L187 D205 E208 D73 G74 D76 L78 D96 E99 H401 Q402 H405 H411 H117 Q118 H121 H127 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 17599356 446 FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY 2ovx A 2.0 BS04 CA A 2 D165 G197 Q199 D201 D56 G88 Q90 D92 H401 Q402 H405 H411 H117 Q118 H121 H127 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 17599356 447 FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY 2ovx A 2.0 BS05 CA A 3 D131 D206 E208 D22 D97 E99 H401 Q402 H405 H411 H117 Q118 H121 H127 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 17599356 448 FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY 2ovx A 2.0 BS06 CA A 4 S211 L212 G215 Q391 G392 Y393 S102 L103 G106 Q107 G108 Y109 H401 Q402 H405 H411 H117 Q118 H121 H127 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 17599356 449 FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY 2ovx A 2.0 BS07 CA A 5 S149 T152 S40 T43 H401 Q402 H405 H411 H117 Q118 H121 H127 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 17599356 450 FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY 2ovx A 2.0 BS08 4MR A 1 L188 A189 H401 Q402 H405 H411 L418 Y420 P421 M422 Y423 L79 A80 H117 Q118 H121 H127 L134 Y136 P137 M138 Y139 H401 Q402 H405 H411 H117 Q118 H121 H127 3.4.24.35 0004222,0006508,0008237,0008270,0031012 -logKd/Ki=8.70, IC50=2nM P14780 17599356 501 FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY 2ovx B 2.0 BS01 ZN B 1 H401 H405 H411 H117 H121 H127 H401 Q402 H405 H411 H117 Q118 H121 H127 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 17599356 444 FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY 2ovx B 2.0 BS02 ZN B 2 H175 D177 H190 H203 H66 D68 H81 H94 H401 Q402 H405 H411 H117 Q118 H121 H127 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 17599356 445 FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY 2ovx B 2.0 BS03 CA B 1 D182 G183 D185 L187 D205 E208 D73 G74 D76 L78 D96 E99 H401 Q402 H405 H411 H117 Q118 H121 H127 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 17599356 446 FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY 2ovx B 2.0 BS04 CA B 2 D165 G197 Q199 D201 D56 G88 Q90 D92 H401 Q402 H405 H411 H117 Q118 H121 H127 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 17599356 447 FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY 2ovx B 2.0 BS05 CA B 3 D131 D206 E208 D22 D97 E99 H401 Q402 H405 H411 H117 Q118 H121 H127 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 17599356 448 FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY 2ovx B 2.0 BS06 CA B 4 S211 L212 G213 K214 G215 S102 L103 G104 K105 G106 H401 Q402 H405 H411 H117 Q118 H121 H127 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 17599356 449 FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY 2ovx B 2.0 BS07 CA B 5 S149 T152 S40 T43 H401 Q402 H405 H411 H117 Q118 H121 H127 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 17599356 450 FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY 2ovx B 2.0 BS08 4MR B 1 L188 A189 H401 Q402 H405 H411 L418 P421 M422 Y423 L79 A80 H117 Q118 H121 H127 L134 P137 M138 Y139 H401 Q402 H405 H411 H117 Q118 H121 H127 3.4.24.35 0004222,0006508,0008237,0008270,0031012 P14780 17599356 502 FEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGQGYSLFLVAAHQFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLY