2oo0 A 1.9 BS01 PLP A 1 A67 K69 D88 H197 S200 G237 E274 G276 R277 Y389 A77 K79 D98 H207 S210 G247 E284 G286 R287 Y386 K69 H197 E274 K79 H207 E284 4.1.1.17 0001822,0003824,0004586,0005515,0005575,0005737,0005829,0006595,0006596,0008283,0008284,0009615,0016831,0033387,0042176,0042803 Kd=0.05uM P11926 17407445 600 AGENLYFQSLMNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQN 2oo0 A 1.9 BS02 XAP A 1 C164 D332 Y389 C174 D329 Y386 K69 H197 E274 K79 H207 E284 4.1.1.17 0001822,0003824,0004586,0005515,0005575,0005737,0005829,0006595,0006596,0008283,0008284,0009615,0016831,0033387,0042176,0042803 Ki=1.4nM P11926 17407445 601 AGENLYFQSLMNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQN 2oo0 A 1.9 BS03 N2P A 1 P239 G240 S241 V244 R277 N385 P249 G250 S251 V254 R287 N382 K69 H197 E274 K79 H207 E284 4.1.1.17 0001822,0003824,0004586,0005515,0005575,0005737,0005829,0006595,0006596,0008283,0008284,0009615,0016831,0033387,0042176,0042803 P11926 17407445 700 AGENLYFQSLMNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQN 2oo0 B 1.9 BS01 PLP B 1 A67 K69 D88 H197 S200 G237 E274 G276 R277 Y389 A76 K78 D97 H206 S209 G246 E283 G285 R286 Y385 K69 H197 E274 K78 H206 E283 4.1.1.17 0001822,0003824,0004586,0005515,0005575,0005737,0005829,0006595,0006596,0008283,0008284,0009615,0016831,0033387,0042176,0042803 Kd=0.05uM P11926 17407445 600 GENLYFQSLMNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQN 2oo0 B 1.9 BS02 XAP B 1 C164 D332 Y389 C173 D328 Y385 K69 H197 E274 K78 H206 E283 4.1.1.17 0001822,0003824,0004586,0005515,0005575,0005737,0005829,0006595,0006596,0008283,0008284,0009615,0016831,0033387,0042176,0042803 Ki=1.4nM P11926 17407445 601 GENLYFQSLMNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQN 2oo0 B 1.9 BS03 N2P B 1 G201 V244 K245 L246 G210 V253 K254 L255 K69 H197 E274 K78 H206 E283 4.1.1.17 0001822,0003824,0004586,0005515,0005575,0005737,0005829,0006595,0006596,0008283,0008284,0009615,0016831,0033387,0042176,0042803 P11926 17407445 700 GENLYFQSLMNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQN