2oic A 2.4 BS01 STU A 1 M192 E194 G195 V200 A211 Y264 M265 G268 A315 N316 L318 M30 E32 G33 V38 A49 Y91 M92 G95 A142 N143 L145 D311 K313 A315 N316 D329 T351 D138 K140 A142 N143 D156 T172 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=4nM -logKd/Ki=8.40, IC50=4nM Q9NWZ3 17312103 1 TRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARATVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 2oic B 2.4 BS01 STU B 1 M192 A211 Y264 M265 G268 A315 L318 M29 A46 Y89 M90 G93 A140 L143 D311 K313 A315 N316 D329 T351 D136 K138 A140 N141 D154 T170 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=4nM Q9NWZ3 17312103 2 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGVVYKGYVNNTTVAVKKLLKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 2oic C 2.4 BS01 STU C 1 M192 G195 A211 Y262 Y264 M265 G268 A315 N316 L318 M32 G35 A51 Y94 Y96 M97 G100 A147 N148 L150 D311 K313 A315 N316 D329 T351 D143 K145 A147 N148 D161 T173 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=4nM Q9NWZ3 17312103 3 SDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMT 2oic D 2.4 BS01 STU D 1 G193 V200 A211 K213 Y262 Y264 M265 G268 A315 L318 S328 G33 V40 A51 K53 Y92 Y94 M95 G98 A145 L148 S158 D311 K313 A315 N316 D329 T351 D141 K143 A145 N146 D159 T179 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=4nM Q9NWZ3 17312103 4 SDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLLKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA