2oc1 A 2.7 BS01 peptide B 0 T4 A5 Y6 A7 Q8 Q9 T10 R11 T19 S20 E30 E32 V33 Q34 I35 V36 S37 R62 T63 I64 R92 R109 T6 A7 Y8 A9 Q10 Q11 T12 R13 T21 S22 E32 E34 V35 Q36 I37 V38 S39 R64 T65 I66 R94 R111 H57 D81 G137 S139 H59 D83 G139 S141 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P27958 17444623 20 ~ 41 MGAPITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMRS 2oc1 A 2.7 BS02 peptide D 0 T4 A5 Y6 A7 T6 A7 Y8 A9 H57 D81 G137 S139 H59 D83 G139 S141 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P27958 17444623 21 ~ 36 MGAPITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMRS 2oc1 A 2.7 BS03 ZN A 1 C97 C99 C145 C99 C101 C147 H57 D81 G137 S139 H59 D83 G139 S141 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P27958 17444623 901 MGAPITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMRS 2oc1 A 2.7 BS04 HU2 A 1 Q41 T42 H57 R109 I132 K136 G137 S139 R155 A156 A157 D168 Q43 T44 H59 R111 I134 K138 G139 S141 R157 A158 A159 D170 H57 D81 G137 S139 H59 D83 G139 S141 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 -logKd/Ki=5.37, Ki=4.3uM P27958 17444623 999 MGAPITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETTMRS 2oc1 C 2.7 BS01 peptide B 0 A111 V113 A83 V85 H57 D81 G137 S139 H29 D53 G109 S111 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P27958 17444623 20 ~ 41 VEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETTM 2oc1 C 2.7 BS02 peptide D 0 V29 G31 E32 V33 I35 V36 S37 R62 T63 I64 A65 W85 P88 G90 V1 G3 E4 V5 I7 V8 S9 R34 T35 I36 A37 W57 P60 G62 H57 D81 G137 S139 H29 D53 G109 S111 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P27958 17444623 21 ~ 36 VEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETTM 2oc1 C 2.7 BS03 ZN C 1 C97 C99 C145 C69 C71 C117 H57 D81 G137 S139 H29 D53 G109 S111 2.7.7.48,3.4.21.98,3.4.22.-,3.6.1.15,3.6.4.13 0006508,0008236,0019087 P27958 17444623 902 VEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETTM