2oax A 2.29 BS01 SNL A 1 L766 L769 N770 L772 Q776 M807 L810 L814 F829 M845 L938 F941 C942 T945 F956 L26 L29 N30 L32 Q36 M67 L70 L74 F89 M105 L189 F192 C193 T196 F207 ? -logKd/Ki=8.65, Ki=2.232nM IC50=11nM, Ki=2.323nM P08235 17569793 1001 PVMVLENIEPEIVYAGYDSDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLLSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFH 2oax B 2.29 BS01 SNL B 1 L766 L769 N770 Q776 M807 L810 L814 F829 L938 F941 C942 F956 L28 L31 N32 Q38 M69 L72 L76 F91 L189 F192 C193 F207 ? IC50=11nM, Ki=2.323nM P08235 17569793 2001 VMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLLSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFH 2oax C 2.29 BS01 SNL C 1 L766 L769 N770 Q776 M807 L810 L814 F829 M845 L848 M852 L938 F941 C942 F956 L26 L29 N30 Q36 M67 L70 L74 F89 M105 L108 M112 L189 F192 C193 F207 ? IC50=11nM, Ki=2.323nM P08235 17569793 3001 PVMVLENIEPEIVYAGYDSDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLLSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFH 2oax D 2.29 BS01 SNL D 1 L766 L769 N770 L772 A773 Q776 M807 L810 L814 F829 M845 M852 L938 F941 C942 F956 L26 L29 N30 L32 A33 Q36 M67 L70 L74 F89 M105 M112 L190 F193 C194 F208 ? IC50=11nM, Ki=2.323nM P08235 17569793 4001 PVMVLENIEPEIVYAGYDSDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLLSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFH 2oax E 2.29 BS01 SNL E 1 L766 L769 N770 L772 Q776 M807 L810 L814 F829 M845 M852 L938 F941 C942 F956 L29 L32 N33 L35 Q39 M70 L73 L77 F92 M108 M115 L190 F193 C194 F208 ? IC50=11nM, Ki=2.323nM P08235 17569793 5001 PVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLLSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFH 2oax F 2.29 BS01 SNL F 1 L769 N770 L772 A773 Q776 M807 L810 F829 C942 F956 L29 N30 L32 A33 Q36 M67 L70 F89 C198 F212 ? IC50=11nM, Ki=2.323nM P08235 17569793 6001 PVMVLENIEPEIVYAGYDSDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLLSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFH