2o9i A 2.8 BS01 peptide C 0 K259 I269 E270 I273 K277 E427 K105 I115 E116 I119 K123 E273 ? 0003677,0004879,0006355 O75469 17215127 625 ~ 639 GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELSQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITG 2o9i A 2.8 BS02 444 A 1 L209 M243 M246 Q285 F288 W299 Y306 H407 L411 F420 L55 M89 M92 Q131 F134 W145 Y152 H253 L257 F266 ? 0003677,0004879,0006355 -logKd/Ki=7.40, IC50=40nM EC50=36nM, IC50=40nM O75469 17215127 2 GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELSQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITG 2o9i B 2.8 BS01 peptide D 0 I1255 K1259 I1269 E1270 Q1272 I1273 K1277 E1427 I101 K105 I115 E116 Q118 I119 K123 E273 ? 0003677,0004879,0006355 O75469 17215127 1625 ~ 1639 GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELSQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITG 2o9i B 2.8 BS02 444 B 1 L1209 M1243 Q1285 F1288 W1299 Y1306 M1323 H1327 H1407 L1411 F1420 L55 M89 Q131 F134 W145 Y152 M169 H173 H253 L257 F266 ? 0003677,0004879,0006355 EC50=36nM, IC50=40nM O75469 17215127 1 GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELSQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITG