2nv7 A 2.1 BS01 peptide C 0 I310 K314 V328 D489 E493 I48 K52 V66 D217 E221 ? 0003677,0004879,0006355 Q92731 17188490 604 ~ 613 LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVL 2nv7 A 2.1 BS02 555 A 1 M295 E305 L339 F356 I373 I376 H475 L476 M33 E43 L77 F94 I111 I114 H203 L204 ? 0003677,0004879,0006355 ic50=5nM -logKd/Ki=8.30, IC50=5nM Q92731 17188490 501 LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVL 2nv7 B 2.1 BS01 peptide D 0 I310 K314 V328 L490 E493 I48 K52 V66 L218 E221 ? 0003677,0004879,0006355 Q92731 17188490 604 ~ 613 LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNA 2nv7 B 2.1 BS02 555 B 1 E305 M336 L339 F356 I373 I376 F377 H475 L476 E43 M74 L77 F94 I111 I114 F115 H203 L204 ? 0003677,0004879,0006355 ic50=5nM Q92731 17188490 501 LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNA