2n27 A -1.00 BS01 CA A 1 D22 G23 D24 G25 T26 D22 G23 D24 G25 T26 V35 V35 ? 0000086,0000922,0002027,0005509,0005513,0005515,0005576,0005634,0005654,0005737,0005813,0005819,0005829,0005856,0005876,0005886,0007186,0008076,0010800,0010801,0010856,0010880,0010881,0016020,0016240,0019855,0019901,0021762,0030017,0031432,0031514,0031954,0031982,0032465,0032516,0032991,0034704,0035307,0035458,0043209,0043539,0044305,0044325,0046427,0046872,0048306,0050848,0051343,0051592,0055117,0060314,0060315,0060316,0071346,0071902,0072542,0097225,0098901,0099523,0140056,0140238,1901020,1901842,1901844,1902494,1905913,1990456 P0DP23 27339229 201 ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK 2n27 A -1.00 BS02 CA A 2 D95 Y99 I100 D95 Y99 I100 V35 V35 ? 0000086,0000922,0002027,0005509,0005513,0005515,0005576,0005634,0005654,0005737,0005813,0005819,0005829,0005856,0005876,0005886,0007186,0008076,0010800,0010801,0010856,0010880,0010881,0016020,0016240,0019855,0019901,0021762,0030017,0031432,0031514,0031954,0031982,0032465,0032516,0032991,0034704,0035307,0035458,0043209,0043539,0044305,0044325,0046427,0046872,0048306,0050848,0051343,0051592,0055117,0060314,0060315,0060316,0071346,0071902,0072542,0097225,0098901,0099523,0140056,0140238,1901020,1901842,1901844,1902494,1905913,1990456 P0DP23 27339229 203 ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK 2n27 A -1.00 BS03 CA A 3 D129 D131 Q135 D129 D131 Q135 V35 V35 ? 0000086,0000922,0002027,0005509,0005513,0005515,0005576,0005634,0005654,0005737,0005813,0005819,0005829,0005856,0005876,0005886,0007186,0008076,0010800,0010801,0010856,0010880,0010881,0016020,0016240,0019855,0019901,0021762,0030017,0031432,0031514,0031954,0031982,0032465,0032516,0032991,0034704,0035307,0035458,0043209,0043539,0044305,0044325,0046427,0046872,0048306,0050848,0051343,0051592,0055117,0060314,0060315,0060316,0071346,0071902,0072542,0097225,0098901,0099523,0140056,0140238,1901020,1901842,1901844,1902494,1905913,1990456 P0DP23 27339229 204 ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK 2n27 A -1.00 BS04 4DY A 1 L32 M76 M109 L32 M76 M109 V35 V35 ? 0000086,0000922,0002027,0005509,0005513,0005515,0005576,0005634,0005654,0005737,0005813,0005819,0005829,0005856,0005876,0005886,0007186,0008076,0010800,0010801,0010856,0010880,0010881,0016020,0016240,0019855,0019901,0021762,0030017,0031432,0031514,0031954,0031982,0032465,0032516,0032991,0034704,0035307,0035458,0043209,0043539,0044305,0044325,0046427,0046872,0048306,0050848,0051343,0051592,0055117,0060314,0060315,0060316,0071346,0071902,0072542,0097225,0098901,0099523,0140056,0140238,1901020,1901842,1901844,1902494,1905913,1990456 -logKd/Ki=6.55, Kd=280nM P0DP23 27339229 205 ADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK