2jbp A 3.31 BS01 P4O A 1 L70 L72 G73 K93 C140 L141 D142 L193 D207 L25 L27 G28 K48 C95 L96 D97 L146 D160 D186 K188 E190 N191 D207 D139 K141 E143 N144 D160 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=8.07, IC50=8.5nM IC50=8.5nM, EC50=49nM P49137 17449059 1351 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNSPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 2jbp B 3.31 BS01 P4O B 1 L70 L72 A91 K93 C140 L141 D207 L25 L27 A46 K48 C95 L96 D162 D186 K188 E190 N191 D207 D141 K143 E145 N146 D162 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 17449059 1351 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 2jbp C 3.31 BS01 P4O C 1 L70 L72 A91 K93 C140 L141 D142 L193 D207 L25 L27 A46 K48 C95 L96 D97 L146 D160 D186 K188 E190 N191 D207 D139 K141 E143 N144 D160 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 17449059 1351 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 2jbp D 3.31 BS01 P4O D 1 L70 L72 G73 K93 L141 D142 L193 D207 L24 L26 G27 K47 L95 D96 L145 D159 D186 K188 E190 N191 D207 D138 K140 E142 N143 D159 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 17449059 1351 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNSPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 2jbp E 3.31 BS01 P4O E 1 L70 G73 L141 D142 L193 T206 D207 L27 G30 L98 D99 L148 T161 D162 D186 K188 E190 N191 D207 D141 K143 E145 N146 D162 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 17449059 1345 PQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKE 2jbp F 3.31 BS01 P4O F 1 L70 L72 A91 K93 C140 L141 D207 L26 L28 A47 K49 C96 L97 D163 D186 K188 E190 N191 D207 D142 K144 E146 N147 D163 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 17449059 1350 QFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERW 2jbp G 3.31 BS01 P4O G 1 L70 L72 A91 K93 C140 L141 D142 D207 L26 L28 A47 K49 C96 L97 D98 D160 D186 K188 E190 N191 D207 S216 D139 K141 E143 N144 D160 S169 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 17449059 1350 QFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNSPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERW 2jbp H 3.31 BS01 P4O H 1 L70 V78 A91 K93 L141 D142 L193 D207 L25 V33 A46 K48 L96 D97 L146 D160 D186 K188 E190 N191 D207 S216 D139 K141 E143 N144 D160 S169 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 17449059 1347 FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDK 2jbp I 3.31 BS01 P4O I 1 L70 A91 C140 L141 L193 D207 L26 A46 C95 L96 L148 D162 D186 K188 E190 N191 D207 D141 K143 E145 N146 D162 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 17449059 1351 QFHVKSGLQIKKNAIIDDYKVTSQVLGLGNGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNSPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE 2jbp K 3.31 BS01 P4O K 1 L70 L72 G73 V78 A91 C140 L141 D207 L24 L26 G27 V32 A45 C94 L95 D159 D186 K188 E190 N191 D207 D138 K140 E142 N143 D159 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 17449059 1345 HVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETDKSCDMWSLGVIMYILLCGYPPFYISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKE 2jbp L 3.31 BS01 P4O L 1 L70 G73 C140 L141 D142 L193 T206 D207 L27 G30 C97 L98 D99 L148 T161 D162 D186 K188 E190 N191 D207 D141 K143 E145 N146 D162 2.7.11.1 0004672,0005524,0006468 IC50=8.5nM, EC50=49nM P49137 17449059 1345 PQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTYDKSCDMWSLGVIMYILLCGYPPFYSNMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKE