2h96 A 3.0 BS01 peptide F 0 R127 Y130 V159 S161 D162 C163 W324 E329 E364 R121 Y124 V153 S155 D156 C157 W318 E323 E358 D151 K153 N156 D169 T188 D145 K147 N150 D163 T182 2.7.11.24 0004672,0004707,0005524,0006468 P45983 16854050 554 ~ 563 DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMEPEVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 2h96 A 3.0 BS02 893 A 1 V40 M108 L110 M111 D112 A113 V158 L168 V34 M102 L104 M105 D106 A107 V152 L162 D151 K153 N156 D169 T188 D145 K147 N150 D163 T182 2.7.11.24 0004672,0004707,0005524,0006468 -logKd/Ki=6.64, IC50=0.23uM IC50=230nM P45983 16854050 901 DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMEPEVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLE 2h96 B 3.0 BS01 peptide G 0 Q117 M121 R127 Y130 K160 S161 D162 C163 K288 W324 E329 L363 Q111 M115 R121 Y124 K154 S155 D156 C157 K282 W318 E323 L357 N156 D169 N150 D163 2.7.11.24 0004672,0004707,0005524,0006468 P45983 16854050 554 ~ 563 DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMEPEVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDL 2h96 B 3.0 BS02 893 B 1 I32 V40 A53 M108 L110 M111 D112 A113 N114 V158 L168 I26 V34 A47 M102 L104 M105 D106 A107 N108 V152 L162 N156 D169 N150 D163 2.7.11.24 0004672,0004707,0005524,0006468 IC50=230nM P45983 16854050 902 DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMEPEVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDL