2gvz A 3.27 BS01 MN A 1 D396 I397 D440 D20 I21 D64 D396 I397 D440 H516 D20 I21 D64 H140 4.6.1.1 0009190,0016849,0035556 P30803 16766715 582 MMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREMTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLSYLNGDYEVEPGCGGERNAYLKEHSIETFLIL 2gvz A 3.27 BS02 FKP A 1 F394 W507 V511 T512 F18 W131 V135 T136 D396 I397 D440 H516 D20 I21 D64 H140 4.6.1.1 0009190,0016849,0035556 P30803 16766715 1 MMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREMTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLSYLNGDYEVEPGCGGERNAYLKEHSIETFLIL 2gvz A 3.27 BS03 ONA A 1 D396 G399 F400 T401 A404 G439 D440 D20 G23 F24 T25 A28 G63 D64 D396 I397 D440 H516 D20 I21 D64 H140 4.6.1.1 0009190,0016849,0035556 -logKd/Ki=6.89, Ki=130nM P30803 16766715 100 MMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREMTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLSYLNGDYEVEPGCGGERNAYLKEHSIETFLIL 2gvz B 3.27 BS01 FKP A 1 F895 K896 S942 F16 K17 S63 S891 I892 S942 R1029 K1065 S12 I13 S63 R140 K176 4.6.1.1 0009190,0016849,0035556 P26769 16766715 1 QSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAIRQYMHIGTMVEFAYALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGDLKTYFVNT 2gvz B 3.27 BS02 ONA A 1 N1022 N1025 N133 N136 S891 I892 S942 R1029 K1065 S12 I13 S63 R140 K176 4.6.1.1 0009190,0016849,0035556 -logKd/Ki=6.89, Ki=130nM P26769 16766715 100 QSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAIRQYMHIGTMVEFAYALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLILQTLGYTCTCRGIINVKGKGDLKTYFVNT 2gvz C 3.27 BS01 MN C 1 S54 T204 D223 S16 T146 D165 E50 T55 R201 D223 Q227 E12 T17 R143 D165 Q169 ? 0003924,0005159,0005525,0005737,0005834,0005886,0007165,0007186,0007189,0007191,0007606,0010856,0016020,0016787,0019001,0031683,0031698,0031748,0031852,0035255,0046872,0051430,0071880 P04896 16766715 396 ATHRLLLLGAGESGKSTIVKQMRILHVGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQDDYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHL 2gvz C 3.27 BS02 GSP C 1 E50 G52 K53 S54 T55 D173 L198 R199 R201 L203 G226 N292 K293 D295 L296 C365 A366 V367 E12 G14 K15 S16 T17 D115 L140 R141 R143 L145 G168 N234 K235 D237 L238 C307 A308 V309 E50 T55 R201 D223 Q227 E12 T17 R143 D165 Q169 ? 0003924,0005159,0005525,0005737,0005834,0005886,0007165,0007186,0007189,0007191,0007606,0010856,0016020,0016787,0019001,0031683,0031698,0031748,0031852,0035255,0046872,0051430,0071880 P04896 16766715 395 ATHRLLLLGAGESGKSTIVKQMRILHVGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQDDYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHL