2g72 A 2.0 BS01 SAM A 1 Y27 Y35 Y40 G79 S80 T83 Y85 D101 F102 L103 N106 D158 V159 A181 F182 C183 V187 Y222 Y11 Y19 Y24 G63 S64 T67 Y69 D85 F86 L87 N90 D142 V143 A165 F166 C167 V171 Y206 2.1.1.28 0004603,0005515,0005829,0008168,0032259,0042418,0042423 P11086 17845018 2001 APGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKV 2g72 A 2.0 BS02 F21 A 1 Y35 N39 Y40 R44 V53 F182 E219 Y222 M258 Y19 N23 Y24 R28 V37 F166 E203 Y206 M242 2.1.1.28 0004603,0005515,0005829,0008168,0032259,0042418,0042423 Ki=315nM -logKd/Ki=6.50, Ki=315nM Ki=1200nM P11086 17845018 4001 APGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKV 2g72 B 2.0 BS01 SAM B 1 Y27 Y35 Y40 S80 G81 T83 Y85 D101 F102 L103 N106 D158 V159 A181 F182 C183 V187 Y222 Y14 Y22 Y27 S67 G68 T70 Y72 D88 F89 L90 N93 D145 V146 A168 F169 C170 V174 Y209 2.1.1.28 0004603,0005515,0005829,0008168,0032259,0042418,0042423 P11086 17845018 2002 PDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKV 2g72 B 2.0 BS02 F21 B 1 Y35 N39 Y40 R44 V53 K57 F182 E219 Y222 D267 Y22 N26 Y27 R31 V40 K44 F169 E206 Y209 D254 2.1.1.28 0004603,0005515,0005829,0008168,0032259,0042418,0042423 Ki=315nM Ki=1200nM P11086 17845018 4002 PDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKV