2g70 A 2.4 BS01 SAM A 1 Y27 Y35 Y40 S80 T83 Y85 D101 F102 N106 D158 V159 A181 F182 C183 V187 Y222 Y8 Y16 Y21 S61 T64 Y66 D82 F83 N87 D139 V140 A162 F163 C164 V168 Y203 2.1.1.28 0004603,0005515,0005829,0008168,0032259,0042418,0042423 P11086 17845018 2001 QAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKV 2g70 A 2.4 BS02 HNT A 1 Y35 N39 Y40 V53 F182 E219 Y222 M258 Y16 N20 Y21 V34 F163 E200 Y203 M239 2.1.1.28 0004603,0005515,0005829,0008168,0032259,0042418,0042423 Ki=17nM -logKd/Ki=7.77, Ki=17nM Ki=17nM P11086 17845018 5001 QAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKV 2g70 A 2.4 BS03 HNT A 2 V250 R251 L253 V231 R232 L234 2.1.1.28 0004603,0005515,0005829,0008168,0032259,0042418,0042423 Ki=17nM -logKd/Ki=7.77, Ki=17nM Ki=17nM P11086 17845018 5003 QAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKV 2g70 B 2.4 BS01 SAM B 1 Y27 Y35 Y40 G79 S80 T83 Y85 D101 F102 N106 D158 V159 A181 F182 V187 Y222 Y12 Y20 Y25 G64 S65 T68 Y70 D86 F87 N91 D143 V144 A166 F167 V172 Y207 2.1.1.28 0004603,0005515,0005829,0008168,0032259,0042418,0042423 P11086 17845018 2002 SAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKV 2g70 B 2.4 BS02 HNT B 1 N39 Y40 R44 V53 F182 E219 D267 N24 Y25 R29 V38 F167 E204 D252 2.1.1.28 0004603,0005515,0005829,0008168,0032259,0042418,0042423 Ki=17nM Ki=17nM P11086 17845018 5002 SAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKV