2fu8 A 1.8 BS01 ZN A 1 H116 H118 H196 H83 H85 H159 H116 H118 D120 H121 H196 Y229 H263 H83 H85 D87 H88 H159 Y190 H224 3.5.2.6 0008270,0008800,0016787,0017001,0030655,0042597,0046677,0046872 P52700 17999929 401 EVPLPQLRAYTVDASWLQPMAPLQIADHTWQIGTEDLTALLVQTPDGAVLLDGGMPQMASHLLDNMKARGVTPRDLRLILLSHAHADHAGPVAELKRRTGAKVAANAESAVLLARGGSDDLHFGDGITYPPANADRIVMDGEVITVGGIVFTAHFMAGHTPGSTAWTWTDTRNGKPVRIAYADSLSAPGYQLQGNPRYPHLIEDYRRSFATVRALPCDVLLTPHPGASNWDYAAGARAGAKALTCKAYADAAEQKFDGQLAKETAG 2fu8 A 1.8 BS02 ZN A 2 D120 H121 H263 D87 H88 H224 H116 H118 D120 H121 H196 Y229 H263 H83 H85 D87 H88 H159 Y190 H224 3.5.2.6 0008270,0008800,0016787,0017001,0030655,0042597,0046677,0046872 P52700 17999929 402 EVPLPQLRAYTVDASWLQPMAPLQIADHTWQIGTEDLTALLVQTPDGAVLLDGGMPQMASHLLDNMKARGVTPRDLRLILLSHAHADHAGPVAELKRRTGAKVAANAESAVLLARGGSDDLHFGDGITYPPANADRIVMDGEVITVGGIVFTAHFMAGHTPGSTAWTWTDTRNGKPVRIAYADSLSAPGYQLQGNPRYPHLIEDYRRSFATVRALPCDVLLTPHPGASNWDYAAGARAGAKALTCKAYADAAEQKFDGQLAKETAG 2fu8 A 1.8 BS03 MCO A 1 Y33 W39 D120 H196 S225 P227 H263 Y10 W16 D87 H159 S186 P188 H224 H116 H118 D120 H121 H196 Y229 H263 H83 H85 D87 H88 H159 Y190 H224 3.5.2.6 0008270,0008800,0016787,0017001,0030655,0042597,0046677,0046872 Ki=20uM -logKd/Ki=4.70, Ki=20uM P52700 17999929 1410 EVPLPQLRAYTVDASWLQPMAPLQIADHTWQIGTEDLTALLVQTPDGAVLLDGGMPQMASHLLDNMKARGVTPRDLRLILLSHAHADHAGPVAELKRRTGAKVAANAESAVLLARGGSDDLHFGDGITYPPANADRIVMDGEVITVGGIVFTAHFMAGHTPGSTAWTWTDTRNGKPVRIAYADSLSAPGYQLQGNPRYPHLIEDYRRSFATVRALPCDVLLTPHPGASNWDYAAGARAGAKALTCKAYADAAEQKFDGQLAKETAG 2fu8 B 1.8 BS01 ZN B 1 H116 H118 H196 H83 H85 H159 H116 H118 D120 H121 H196 Y229 H263 H83 H85 D87 H88 H159 Y190 H224 3.5.2.6 0008270,0008800,0016787,0017001,0030655,0042597,0046677,0046872 P52700 17999929 401 EVPLPQLRAYTVDASWLQPMAPLQIADHTWQIGTEDLTALLVQTPDGAVLLDGGMPQMASHLLDNMKARGVTPRDLRLILLSHAHADHAGPVAELKRRTGAKVAANAESAVLLARGGSDDLHFGDGITYPPANADRIVMDGEVITVGGIVFTAHFMAGHTPGSTAWTWTDTRNGKPVRIAYADSLSAPGYQLQGNPRYPHLIEDYRRSFATVRALPCDVLLTPHPGASNWDYAAGARAGAKALTCKAYADAAEQKFDGQLAKETAG 2fu8 B 1.8 BS02 ZN B 2 D120 H121 H263 D87 H88 H224 H116 H118 D120 H121 H196 Y229 H263 H83 H85 D87 H88 H159 Y190 H224 3.5.2.6 0008270,0008800,0016787,0017001,0030655,0042597,0046677,0046872 P52700 17999929 402 EVPLPQLRAYTVDASWLQPMAPLQIADHTWQIGTEDLTALLVQTPDGAVLLDGGMPQMASHLLDNMKARGVTPRDLRLILLSHAHADHAGPVAELKRRTGAKVAANAESAVLLARGGSDDLHFGDGITYPPANADRIVMDGEVITVGGIVFTAHFMAGHTPGSTAWTWTDTRNGKPVRIAYADSLSAPGYQLQGNPRYPHLIEDYRRSFATVRALPCDVLLTPHPGASNWDYAAGARAGAKALTCKAYADAAEQKFDGQLAKETAG 2fu8 B 1.8 BS03 MCO B 1 Y33 W39 D120 H196 S225 P227 H263 Y10 W16 D87 H159 S186 P188 H224 H116 H118 D120 H121 H196 Y229 H263 H83 H85 D87 H88 H159 Y190 H224 3.5.2.6 0008270,0008800,0016787,0017001,0030655,0042597,0046677,0046872 Ki=20uM P52700 17999929 2410 EVPLPQLRAYTVDASWLQPMAPLQIADHTWQIGTEDLTALLVQTPDGAVLLDGGMPQMASHLLDNMKARGVTPRDLRLILLSHAHADHAGPVAELKRRTGAKVAANAESAVLLARGGSDDLHFGDGITYPPANADRIVMDGEVITVGGIVFTAHFMAGHTPGSTAWTWTDTRNGKPVRIAYADSLSAPGYQLQGNPRYPHLIEDYRRSFATVRALPCDVLLTPHPGASNWDYAAGARAGAKALTCKAYADAAEQKFDGQLAKETAG