2fsz A 2.2 BS01 OHT A 1 M295 L298 T299 L301 A302 D303 E305 M336 G472 L476 M32 L35 T36 L38 A39 D40 E42 M73 G197 L201 ? IC50=20nM, Ki=0.16nM, EC50=32nM Q92731 16782818 101 SPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESSWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKSVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMNVVPVYDLLLEMLNAHVLR 2fsz A 2.2 BS02 OHT A 2 L306 I310 K314 V328 L331 E332 W335 L43 I47 K51 V65 L68 E69 W72 ? IC50=20nM, Ki=0.16nM, EC50=32nM Q92731 16782818 103 SPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESSWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKSVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMNVVPVYDLLLEMLNAHVLR 2fsz B 2.2 BS01 OHT B 1 M295 L298 A302 D303 E305 M336 L476 M36 L39 A43 D44 E46 M77 L205 ? IC50=20nM, Ki=0.16nM, EC50=32nM Q92731 16782818 102 LDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESSWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKSVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMNVVPVYDLLLEMLNAHVLR 2fsz B 2.2 BS02 OHT B 2 L306 I310 Q327 V328 L331 E332 W335 L47 I51 Q68 V69 L72 E73 W76 ? IC50=20nM, Ki=0.16nM, EC50=32nM Q92731 16782818 104 LDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESSWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKSVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMNVVPVYDLLLEMLNAHVLR