2fgi A 2.5 BS01 PD1 A 1 L484 G485 V492 A512 K514 M535 I545 V561 Y563 A564 S565 G567 L630 A640 D641 L21 G22 V24 A40 K42 M63 I73 V89 Y91 A92 S93 G95 L144 A154 D155 D623 A625 R627 N628 D641 D137 A139 R141 N142 D155 2.7.10.1 0004672,0004713,0005007,0005524,0006468 Ki=36.4nM -logKd/Ki=7.34, Ki=45.2nM IC50=22nM, EC50=21nM P11362 9774334 1001 ELPEDPRWELPRDRLVLGKPLGQVVLAEAIGLPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLADIHHIDYYKKTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTS 2fgi B 2.5 BS01 PD1 B 1 L484 G485 E486 V492 A512 K514 E531 I545 V561 Y563 A564 L630 D641 L24 G25 E26 V32 A48 K50 E67 I81 V97 Y99 A100 L150 D161 D623 A625 R627 N628 D641 D143 A145 R147 N148 D161 2.7.10.1 0004672,0004713,0005007,0005524,0006468 Ki=36.4nM IC50=22nM, EC50=21nM P11362 9774334 1000 SEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLADYYKKGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT