2fdv A 1.65 BS01 HEM A 1 R101 V117 R128 G302 T305 R372 P431 F432 S433 R437 C439 F440 G441 R72 V88 R99 G273 T276 R343 P402 F403 S404 R408 C410 F411 G412 T305 F432 C439 T276 F403 C410 1.14.14.- 0004497,0005506,0005515,0005737,0005783,0005789,0005881,0006629,0006805,0008202,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0019899,0020037,0042178,0043231,0046226,0046872 P11509 17125252 500 KGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 2fdv A 1.65 BS02 D2G A 1 F107 F111 N297 I300 G301 T305 F480 F78 F82 N268 I271 G272 T276 F451 T305 F432 C439 T276 F403 C410 1.14.14.- 0004497,0005506,0005515,0005737,0005783,0005789,0005881,0006629,0006805,0008202,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0019899,0020037,0042178,0043231,0046226,0046872 Ki=800nM IC50=1.65e+3nM, Ki=800nM P11509 17125252 501 KGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 2fdv B 1.65 BS01 HEM B 1 R101 V117 R128 G302 T305 R372 P431 F432 S433 R437 N438 C439 F440 G441 R70 V86 R97 G271 T274 R341 P400 F401 S402 R406 N407 C408 F409 G410 T305 F432 C439 T274 F401 C408 1.14.14.- 0004497,0005506,0005515,0005737,0005783,0005789,0005881,0006629,0006805,0008202,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0019899,0020037,0042178,0043231,0046226,0046872 P11509 17125252 500 KLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPRHH 2fdv B 1.65 BS02 D2G B 1 F107 F111 F118 N297 I300 G301 T305 F480 F76 F80 F87 N266 I269 G270 T274 F449 T305 F432 C439 T274 F401 C408 1.14.14.- 0004497,0005506,0005515,0005737,0005783,0005789,0005881,0006629,0006805,0008202,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0019899,0020037,0042178,0043231,0046226,0046872 Ki=800nM IC50=1.65e+3nM, Ki=800nM P11509 17125252 501 KLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPRHH 2fdv C 1.65 BS01 HEM C 1 R101 V117 R128 G302 T305 R372 P431 F432 S433 R437 C439 F440 G441 R71 V87 R98 G272 T275 R342 P401 F402 S403 R407 C409 F410 G411 T305 F432 C439 T275 F402 C409 1.14.14.- 0004497,0005506,0005515,0005737,0005783,0005789,0005881,0006629,0006805,0008202,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0019899,0020037,0042178,0043231,0046226,0046872 P11509 17125252 500 GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 2fdv C 1.65 BS02 D2G C 1 F107 F111 N297 G301 T305 F480 F77 F81 N267 G271 T275 F450 T305 F432 C439 T275 F402 C409 1.14.14.- 0004497,0005506,0005515,0005737,0005783,0005789,0005881,0006629,0006805,0008202,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0019899,0020037,0042178,0043231,0046226,0046872 Ki=800nM IC50=1.65e+3nM, Ki=800nM P11509 17125252 501 GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 2fdv D 1.65 BS01 HEM D 1 R101 V117 R128 G302 T305 R372 P431 F432 S433 R437 C439 F440 G441 R71 V87 R98 G272 T275 R342 P401 F402 S403 R407 C409 F410 G411 T305 F432 C439 T275 F402 C409 1.14.14.- 0004497,0005506,0005515,0005737,0005783,0005789,0005881,0006629,0006805,0008202,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0019899,0020037,0042178,0043231,0046226,0046872 P11509 17125252 500 GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 2fdv D 1.65 BS02 D2G D 1 F107 F111 N297 I300 G301 T305 F480 F77 F81 N267 I270 G271 T275 F450 T305 F432 C439 T275 F402 C409 1.14.14.- 0004497,0005506,0005515,0005737,0005783,0005789,0005881,0006629,0006805,0008202,0008389,0008392,0009804,0016020,0016705,0016712,0019373,0019899,0020037,0042178,0043231,0046226,0046872 Ki=800nM IC50=1.65e+3nM, Ki=800nM P11509 17125252 501 GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR