2eg8 A 2.2 BS01 ZN A 1 K102 H139 H177 K99 H136 H174 H16 H18 K102 H139 H177 D250 H13 H15 K99 H136 H174 D247 3.5.2.3 0004151,0005737,0005829,0006207,0006221,0008270,0016787,0016812,0019856,0042803,0044205,0046872 P05020 17550785 400 SQVLKIRRPDDWHLHLRDGDMLKTVVPYTSEIYGRAIVMPNLAPPVTTVEAAVAYRQRILDAVPAGHDFTPLMTCYLTDSLDPNELERGFNEGVFTAAKLYPANATTNSSHGVTSVDAIMPVLERMEKIGMPLLVHGEVTHADIDIFDREARFIESVMEPLRQRLTALKVVFEHITTKDAADYVRDGNERLAATITPQHLMFNRNHMLVGGVRPHLYCLPILKRNIHQQALRELVASGFNRVFLGTDSAPHARHRKESSCGCAGCFNAPTALGSYATVFEEMNALQHFEAFCSVNGPQFYGLPVNDTFIELVREEQQVAESIALTDDTLVPFLAGETVRWSVK 2eg8 A 2.2 BS02 ZN A 2 H16 H18 K102 D250 H13 H15 K99 D247 H16 H18 K102 H139 H177 D250 H13 H15 K99 H136 H174 D247 3.5.2.3 0004151,0005737,0005829,0006207,0006221,0008270,0016787,0016812,0019856,0042803,0044205,0046872 P05020 17550785 401 SQVLKIRRPDDWHLHLRDGDMLKTVVPYTSEIYGRAIVMPNLAPPVTTVEAAVAYRQRILDAVPAGHDFTPLMTCYLTDSLDPNELERGFNEGVFTAAKLYPANATTNSSHGVTSVDAIMPVLERMEKIGMPLLVHGEVTHADIDIFDREARFIESVMEPLRQRLTALKVVFEHITTKDAADYVRDGNERLAATITPQHLMFNRNHMLVGGVRPHLYCLPILKRNIHQQALRELVASGFNRVFLGTDSAPHARHRKESSCGCAGCFNAPTALGSYATVFEEMNALQHFEAFCSVNGPQFYGLPVNDTFIELVREEQQVAESIALTDDTLVPFLAGETVRWSVK 2eg8 A 2.2 BS03 FOT A 1 R20 N44 H139 C221 L222 H254 A266 G267 R17 N41 H136 C218 L219 H251 A263 G264 H16 H18 K102 H139 H177 D250 H13 H15 K99 H136 H174 D247 3.5.2.3 0004151,0005737,0005829,0006207,0006221,0008270,0016787,0016812,0019856,0042803,0044205,0046872 Ki=31.8uM -logKd/Ki=4.50, Ki=31.8uM P05020 17550785 410 SQVLKIRRPDDWHLHLRDGDMLKTVVPYTSEIYGRAIVMPNLAPPVTTVEAAVAYRQRILDAVPAGHDFTPLMTCYLTDSLDPNELERGFNEGVFTAAKLYPANATTNSSHGVTSVDAIMPVLERMEKIGMPLLVHGEVTHADIDIFDREARFIESVMEPLRQRLTALKVVFEHITTKDAADYVRDGNERLAATITPQHLMFNRNHMLVGGVRPHLYCLPILKRNIHQQALRELVASGFNRVFLGTDSAPHARHRKESSCGCAGCFNAPTALGSYATVFEEMNALQHFEAFCSVNGPQFYGLPVNDTFIELVREEQQVAESIALTDDTLVPFLAGETVRWSVK 2eg8 B 2.2 BS01 ZN B 1 K102 H139 H177 K99 H129 H167 H16 H18 K102 H139 H177 D250 H13 H15 K99 H129 H167 D240 3.5.2.3 0004151,0005737,0005829,0006207,0006221,0008270,0016787,0016812,0019856,0042803,0044205,0046872 P05020 17550785 400 SQVLKIRRPDDWHLHLRDGDMLKTVVPYTSEIYGRAIVMPNLAPPVTTVEAAVAYRQRILDAVPAGHDFTPLMTCYLTDSLDPNELERGFNEGVFTAAKLYPANGVTSVDAIMPVLERMEKIGMPLLVHGEVTHADIDIFDREARFIESVMEPLRQRLTALKVVFEHITTKDAADYVRDGNERLAATITPQHLMFNRNHMLVGGVRPHLYCLPILKRNIHQQALRELVASGFNRVFLGTDSAPHARHRKESSCGCAGCFNAPTALGSYATVFEEMNALQHFEAFCSVNGPQFYGLPVNDTFIELVREEQQVAESIALTDDTLVPFLAGETVRWSVK 2eg8 B 2.2 BS02 ZN B 2 H16 H18 K102 D250 H13 H15 K99 D240 H16 H18 K102 H139 H177 D250 H13 H15 K99 H129 H167 D240 3.5.2.3 0004151,0005737,0005829,0006207,0006221,0008270,0016787,0016812,0019856,0042803,0044205,0046872 P05020 17550785 401 SQVLKIRRPDDWHLHLRDGDMLKTVVPYTSEIYGRAIVMPNLAPPVTTVEAAVAYRQRILDAVPAGHDFTPLMTCYLTDSLDPNELERGFNEGVFTAAKLYPANGVTSVDAIMPVLERMEKIGMPLLVHGEVTHADIDIFDREARFIESVMEPLRQRLTALKVVFEHITTKDAADYVRDGNERLAATITPQHLMFNRNHMLVGGVRPHLYCLPILKRNIHQQALRELVASGFNRVFLGTDSAPHARHRKESSCGCAGCFNAPTALGSYATVFEEMNALQHFEAFCSVNGPQFYGLPVNDTFIELVREEQQVAESIALTDDTLVPFLAGETVRWSVK 2eg8 B 2.2 BS03 FOT B 1 R20 N44 H139 C221 L222 H254 A266 G267 R17 N41 H129 C211 L212 H244 A256 G257 H16 H18 K102 H139 H177 D250 H13 H15 K99 H129 H167 D240 3.5.2.3 0004151,0005737,0005829,0006207,0006221,0008270,0016787,0016812,0019856,0042803,0044205,0046872 Ki=31.8uM P05020 17550785 410 SQVLKIRRPDDWHLHLRDGDMLKTVVPYTSEIYGRAIVMPNLAPPVTTVEAAVAYRQRILDAVPAGHDFTPLMTCYLTDSLDPNELERGFNEGVFTAAKLYPANGVTSVDAIMPVLERMEKIGMPLLVHGEVTHADIDIFDREARFIESVMEPLRQRLTALKVVFEHITTKDAADYVRDGNERLAATITPQHLMFNRNHMLVGGVRPHLYCLPILKRNIHQQALRELVASGFNRVFLGTDSAPHARHRKESSCGCAGCFNAPTALGSYATVFEEMNALQHFEAFCSVNGPQFYGLPVNDTFIELVREEQQVAESIALTDDTLVPFLAGETVRWSVK