2c8y B 2.2 BS01 peptide A 0 E23 I24 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 P204 N205 R206 W207 E8 I9 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N156 M203 K204 P206 N209 R210 W211 H57 D102 E192 G193 D194 S195 G196 H43 D99 E194 G195 D196 S197 G198 3.4.21.5 0004252,0005509,0006508,0007596 P00734 16480269 -3 ~ 14K IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 2c8y B 2.2 BS02 peptide I 0 F34 L65 R67 R73 T74 R75 Y76 K81 I82 F19 L60 R62 R68 T69 R70 Y71 K77 I78 H57 D102 E192 G193 D194 S195 G196 H43 D99 E194 G195 D196 S197 G198 3.4.21.5 0004252,0005509,0006508,0007596 P00734 16480269 55 ~ 64 IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 2c8y B 2.2 BS03 C3M B 1 H57 Y60A W60D N98 L99 W215 G216 H43 Y47 W50 N95 L96 W219 G220 H57 D102 E192 G193 D194 S195 G196 H43 D99 E194 G195 D196 S197 G198 3.4.21.5 0004252,0005509,0006508,0007596 -logKd/Ki=4.00, IC50=100uM IC50=100000nM P00734 16480269 1252 IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE