2c4f H 1.72 BS01 CA H 1 E70 D72 E75 E80 E58 D60 E63 E68 3.4.21.21 0004252,0006508 P08709 16289811 301 IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP 2c4f H 1.72 BS02 GIL H 1 H57 T99 D189 S190 K192 G193 S195 V213 S214 W215 G216 H41 T87 D186 S187 K189 G190 S192 V210 S211 W212 G213 3.4.21.21 0004252,0006508 -logKd/Ki=7.70, IC50=20nM IC50=20nM P08709 16289811 302 IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP 2c4f L 1.72 BS01 CA L 1 D46 G47 Q49 D63 Q64 D43 G44 Q46 D60 Q61 3.4.21.21 0005509,0005576 P08709 16289811 201 FLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 2c4f L 1.72 BS02 GLC L 1 Q49 S52 Y68 Q46 S49 Y65 3.4.21.21 0005509,0005576 P08709 16289811 202 FLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 2c4f L 1.72 BS03 FUC L 1 G58 S60 L73 G55 S57 L70 3.4.21.21 0005509,0005576 P08709 16289811 203 FLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 2c4f L 1.72 BS04 CA L 2 E16 E26 E13 E23 3.4.21.21 0005509,0005576 P08709 16289811 204 FLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 2c4f L 1.72 BS05 CA L 3 E14 E19 E11 E16 3.4.21.21 0005509,0005576 P08709 16289811 205 FLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 2c4f L 1.72 BS06 CA L 4 E25 E29 E22 E26 3.4.21.21 0005509,0005576 P08709 16289811 206 FLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE