2bxs A 3.15 BS01 FAD A 1 I19 G22 S24 E43 G50 R51 G66 G67 A68 Y69 P243 V244 I273 W397 Y402 C406 Y407 T435 G443 Y444 M445 I8 G11 S13 E32 G39 R40 G55 G56 A57 Y58 P227 V228 I257 W381 Y386 C390 Y391 T419 G427 Y428 M429 G71 R206 K305 G60 R190 K289 1.4.3.21,1.4.3.4 0005515,0005739,0005741,0005829,0006576,0006584,0008131,0009967,0016491,0042420,0050660,0052595,0097621 P21397 16129825 600 HMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIG 2bxs A 3.15 BS02 MLG A 1 E216 I335 L337 F352 Y407 E200 I319 L321 F336 Y391 G71 R206 K305 G60 R190 K289 1.4.3.21,1.4.3.4 0005515,0005739,0005741,0005829,0006576,0006584,0008131,0009967,0016491,0042420,0050660,0052595,0097621 IC50=4.5nM, Ki=12nM P21397 16129825 601 HMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIG 2bxs B 3.15 BS01 FAD B 1 I19 G20 G22 S24 L42 E43 G50 R51 G66 G67 A68 Y69 P243 V244 I273 W397 Y402 C406 Y407 G434 T435 G443 Y444 M445 I8 G9 G11 S13 L31 E32 G39 R40 G55 G56 A57 Y58 P227 V228 I257 W381 Y386 C390 Y391 G418 T419 G427 Y428 M429 G71 R206 K305 G60 R190 K289 1.4.3.21,1.4.3.4 0005515,0005739,0005741,0005829,0006576,0006584,0008131,0009967,0016491,0042420,0050660,0052595,0097621 P21397 16129825 600 HMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIG 2bxs B 3.15 BS02 MLG B 1 E216 I335 L337 F352 Y407 E200 I319 L321 F336 Y391 G71 R206 K305 G60 R190 K289 1.4.3.21,1.4.3.4 0005515,0005739,0005741,0005829,0006576,0006584,0008131,0009967,0016491,0042420,0050660,0052595,0097621 IC50=4.5nM, Ki=12nM P21397 16129825 601 HMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIG