2ay7 A 2.4 BS01 PLP A 1 G107 G108 T109 W140 D222 A224 Y225 S255 S257 K258 R266 G99 G100 T101 W127 D208 A210 Y211 S240 S242 K243 R251 W140 D222 A224 K258 W127 D208 A210 K243 2.6.1.57 0004069,0004838,0005737,0005829,0006520,0008483,0008652,0008793,0009058,0009073,0030170,0033585,0042802,0080130 P95468 9930977 413 MLGNLKPQAPDKILALMGEFRADPRQGKIDLGVGVYKDATGHTPIMRAVHAAEQRMLETETTKTYAGLSGEPEFQKAMGELILGDGLKSETTATLATVGGTGALRQALELARMANPDLRVFVSDPTWPNHVSIMNFMGLPVQTYRYFDAETRGVDFEGMKADLAAAKKGDMVLLHGCCHNPTGANLTLDQWAEIASILEKTGALPLIDLAYQGFGDGLEEDAAGTRLIASRIPEVLIAASCSKNFGIYRERTGCLLALCADAATRELAQGAMAFLNRQTYSFPPFHGAKIVSTVLTTPELRADWMAELEAVRSGMLRLREQLAGELRDLSGSDRFGFVAEHRGMFSRLGATPEQVKRIKEEFGIYMVGDSRINIAGLNDNTIPILARAIIEVGV 2ay7 A 2.4 BS02 CLT B 1 Y70 S296 Y65 S281 W140 D222 A224 K258 W127 D208 A210 K243 2.6.1.57 0004069,0004838,0005737,0005829,0006520,0008483,0008652,0008793,0009058,0009073,0030170,0033585,0042802,0080130 -logKd/Ki=2.30, Kd=5.0mM P95468 9930977 414 MLGNLKPQAPDKILALMGEFRADPRQGKIDLGVGVYKDATGHTPIMRAVHAAEQRMLETETTKTYAGLSGEPEFQKAMGELILGDGLKSETTATLATVGGTGALRQALELARMANPDLRVFVSDPTWPNHVSIMNFMGLPVQTYRYFDAETRGVDFEGMKADLAAAKKGDMVLLHGCCHNPTGANLTLDQWAEIASILEKTGALPLIDLAYQGFGDGLEEDAAGTRLIASRIPEVLIAASCSKNFGIYRERTGCLLALCADAATRELAQGAMAFLNRQTYSFPPFHGAKIVSTVLTTPELRADWMAELEAVRSGMLRLREQLAGELRDLSGSDRFGFVAEHRGMFSRLGATPEQVKRIKEEFGIYMVGDSRINIAGLNDNTIPILARAIIEVGV 2ay7 B 2.4 BS01 PLP B 1 G108 T109 W140 N194 D222 A224 Y225 S255 S257 K258 R266 G94 T95 W121 N174 D202 A204 Y205 S234 S236 K237 R245 W140 D222 A224 K258 W121 D202 A204 K237 2.6.1.57 0004069,0004838,0005737,0005829,0006520,0008483,0008652,0008793,0009058,0009073,0030170,0033585,0042802,0080130 P95468 9930977 413 MLGNLKPQAPDKILALMGEFGKIDLGVGVYKDATGHTPIMRAVHAAEQRMLETETTKTYAGLSGEPEFQKAMGELILGDGLKSETTATLATVGGTGALRQALELARMANPDLRVFVSDPTWPNHVSIMNFMGLPVQTYRYFDAETRGVDFEGMKADLAAAKKGDMVLLHGCCHNPTGANLTLDQWAEIASILEKTGALPLIDLAYQGFGDGLEEDAAGTRLIASRIPEVLIAASCSKNFGIYRERTGCLLALCADAATRELAQGAMAFLNRQTYSFPPFHGAKIVSTVLTTPELRADWMAELEAVRSGMLRLREQLAGELRDLSGSDRFGFVAEHRGMFSRLGATPEQVKRIKEEFGIYMVGDSRINIAGLNDNTIPILARAIIEVGV 2ay7 B 2.4 BS02 CLT B 1 G38 W140 N142 N194 R386 G28 W121 N123 N174 R365 W140 D222 A224 K258 W121 D202 A204 K237 2.6.1.57 0004069,0004838,0005737,0005829,0006520,0008483,0008652,0008793,0009058,0009073,0030170,0033585,0042802,0080130 Kd=5mM -logKd/Ki=2.30, Kd=5.0mM P95468 9930977 414 MLGNLKPQAPDKILALMGEFGKIDLGVGVYKDATGHTPIMRAVHAAEQRMLETETTKTYAGLSGEPEFQKAMGELILGDGLKSETTATLATVGGTGALRQALELARMANPDLRVFVSDPTWPNHVSIMNFMGLPVQTYRYFDAETRGVDFEGMKADLAAAKKGDMVLLHGCCHNPTGANLTLDQWAEIASILEKTGALPLIDLAYQGFGDGLEEDAAGTRLIASRIPEVLIAASCSKNFGIYRERTGCLLALCADAATRELAQGAMAFLNRQTYSFPPFHGAKIVSTVLTTPELRADWMAELEAVRSGMLRLREQLAGELRDLSGSDRFGFVAEHRGMFSRLGATPEQVKRIKEEFGIYMVGDSRINIAGLNDNTIPILARAIIEVGV