2afx A 1.64 BS01 ZN A 1 D159 E202 H330 D127 E164 H292 2.3.2.5 0005515,0005576,0008270,0016603,0016746,0017186,0035580,0036211,0046872,0070062,1904724,1904813 Q16769 16135565 996 ASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL 2afx A 1.64 BS02 1BN A 1 D159 E201 E202 D248 Q304 F325 W329 H330 D127 E163 E164 D210 Q266 F287 W291 H292 2.3.2.5 0005515,0005576,0008270,0016603,0016746,0017186,0035580,0036211,0046872,0070062,1904724,1904813 -logKd/Ki=5.15, Ki=7.1uM Ki=262nM Q16769 16135565 1501 ASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL 2afx B 1.64 BS01 ZN B 1 D159 E202 H330 D127 E164 H292 2.3.2.5 0005515,0005576,0008270,0016603,0016746,0017186,0035580,0036211,0046872,0070062,1904724,1904813 Q16769 16135565 997 ASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL 2afx B 1.64 BS02 1BN B 1 D159 E201 E202 W207 D248 Q304 F325 W329 H330 D127 E163 E164 W169 D210 Q266 F287 W291 H292 2.3.2.5 0005515,0005576,0008270,0016603,0016746,0017186,0035580,0036211,0046872,0070062,1904724,1904813 Ki=262nM Q16769 16135565 2501 ASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL