2abj A 2.2 BS01 CBC A 1 F47 F93 Y159 Y191 K220 Q242 T258 M259 G330 A332 C333 F29 F75 Y141 Y173 K202 Q224 T240 M241 G312 A314 C315 K220 K202 2.6.1.42 0000082,0003824,0004084,0005737,0005739,0005829,0006629,0008483,0008652,0009081,0009082,0009098,0009099,0050048,0052654,0052655,0052656 ic50=0.8uM IC50=230nM P54687 16143519 1401 VVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPAFIGTEPSLGVKKPTKALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEDVDNGCQQVLWLYGRDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFSSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLS 2abj A 2.2 BS02 PLP A 1 R117 R210 K220 Y225 E255 T258 M259 N260 L284 G286 V287 T288 T331 R99 R192 K202 Y207 E237 T240 M241 N242 L266 G268 V269 T270 T313 K220 K202 2.6.1.42 0000082,0003824,0004084,0005737,0005739,0005829,0006629,0008483,0008652,0009081,0009082,0009098,0009099,0050048,0052654,0052655,0052656 P54687 16143519 420 VVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPAFIGTEPSLGVKKPTKALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEDVDNGCQQVLWLYGRDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFSSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLS 2abj D 2.2 BS01 CBC D 1 F47 F93 Y159 K220 Q242 T258 M259 G330 A332 C333 F29 F75 Y141 K196 Q218 T234 M235 G306 A308 C309 K220 K196 2.6.1.42 0000082,0003824,0004084,0005737,0005739,0005829,0006629,0008483,0008652,0009081,0009082,0009098,0009099,0050048,0052654,0052655,0052656 ic50=0.8uM IC50=230nM P54687 16143519 2401 VVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPAFIGTEPSLGVKKPTKALLFVLLSPVGPFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEDVDNGCQQVLWLYGRDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFSSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVL 2abj D 2.2 BS02 PLP D 1 R117 K220 Y225 E255 T258 M259 N260 L284 G286 V287 T288 T331 R99 K196 Y201 E231 T234 M235 N236 L260 G262 V263 T264 T307 K220 K196 2.6.1.42 0000082,0003824,0004084,0005737,0005739,0005829,0006629,0008483,0008652,0009081,0009082,0009098,0009099,0050048,0052654,0052655,0052656 P54687 16143519 420 VVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPAFIGTEPSLGVKKPTKALLFVLLSPVGPFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEDVDNGCQQVLWLYGRDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFSSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVL 2abj G 2.2 BS01 CBC G 1 F47 F93 K220 Q242 T258 M259 G330 A332 C333 C336 F27 F73 K194 Q216 T232 M233 G304 A306 C307 C310 2.6.1.42 0000082,0003824,0004084,0005737,0005739,0005829,0006629,0008483,0008652,0009081,0009082,0009098,0009099,0050048,0052654,0052655,0052656 ic50=0.8uM IC50=230nM P54687 16143519 3401 GTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPAFIGTEPSLGVKKPTKALLFVLLSPVGPFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEDVDNGCQQVLWLYGRDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFSSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLS 2abj G 2.2 BS02 PLP G 1 R117 K220 Y225 E255 T258 M259 N260 L284 G286 V287 T288 G330 T331 R97 K194 Y199 E229 T232 M233 N234 L258 G260 V261 T262 G304 T305 2.6.1.42 0000082,0003824,0004084,0005737,0005739,0005829,0006629,0008483,0008652,0009081,0009082,0009098,0009099,0050048,0052654,0052655,0052656 P54687 16143519 420 GTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPAFIGTEPSLGVKKPTKALLFVLLSPVGPFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEDVDNGCQQVLWLYGRDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFSSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLS 2abj J 2.2 BS01 CBC G 1 Y88 V173 Y70 V155 2.6.1.42 0000082,0003824,0004084,0005737,0005739,0005829,0006629,0008483,0008652,0009081,0009082,0009098,0009099,0050048,0052654,0052655,0052656 ic50=0.8uM IC50=230nM P54687 16143519 3401 VVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPAFIGTEPSLGVKKPTKALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEDVDNGCQQVLWLYGRDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFSSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLS 2abj J 2.2 BS02 CBC J 1 F47 F93 Y159 Y191 K220 Q242 T258 M259 G330 A332 C333 F29 F75 Y141 Y173 K202 Q224 T240 M241 G312 A314 C315 2.6.1.42 0000082,0003824,0004084,0005737,0005739,0005829,0006629,0008483,0008652,0009081,0009082,0009098,0009099,0050048,0052654,0052655,0052656 ic50=0.8uM IC50=230nM P54687 16143519 4401 VVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPAFIGTEPSLGVKKPTKALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEDVDNGCQQVLWLYGRDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFSSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLS 2abj J 2.2 BS03 PLP J 1 R117 R210 K220 Y225 E255 T258 M259 N260 L284 G286 V287 T288 T331 R99 R192 K202 Y207 E237 T240 M241 N242 L266 G268 V269 T270 T313 2.6.1.42 0000082,0003824,0004084,0005737,0005739,0005829,0006629,0008483,0008652,0009081,0009082,0009098,0009099,0050048,0052654,0052655,0052656 P54687 16143519 420 VVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPAFIGTEPSLGVKKPTKALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEDVDNGCQQVLWLYGRDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFSSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLS