2a3x A 3.0 BS01 CA A 1 D58 N59 E136 Q137 D138 D58 N59 E136 Q137 D138 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 301 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x A 3.0 BS02 CA A 2 E136 D138 Q148 E136 D138 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 302 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x B 3.0 BS01 CA B 1 D58 N59 E136 Q137 D138 D58 N59 E136 Q137 D138 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 303 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x B 3.0 BS02 CA B 2 E136 D138 D145 Q148 E136 D138 D145 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 304 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x C 3.0 BS01 CA C 1 D58 N59 E136 Q137 D138 D58 N59 E136 Q137 D138 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 305 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x C 3.0 BS02 CA C 2 E136 D138 Q148 E136 D138 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 306 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x C 3.0 BS03 CPK C 1 N59 Y64 Y74 E136 Q148 N59 Y64 Y74 E136 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 402 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x D 3.0 BS01 CA D 1 D58 N59 E136 Q137 D138 D58 N59 E136 Q137 D138 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 307 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x D 3.0 BS02 CA D 2 D138 Q148 D138 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 308 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x D 3.0 BS03 CPK I 1 N59 Y74 E136 D138 Q148 N59 Y74 E136 D138 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 -logKd/Ki=6.92, IC50=0.12uM P02743 16036920 401 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x E 3.0 BS01 CA E 1 D58 N59 E136 Q137 D138 D58 N59 E136 Q137 D138 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 309 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x E 3.0 BS02 CA E 2 E136 D138 Q148 E136 D138 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 310 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x E 3.0 BS03 CPK H 1 N59 Y64 Y74 E136 D138 Q148 N59 Y64 Y74 E136 D138 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 403 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x F 3.0 BS01 CA F 1 N59 E136 D138 N59 E136 D138 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 311 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x F 3.0 BS02 CA F 2 E136 D138 F144 D145 Q148 E136 D138 F144 D145 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 312 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x G 3.0 BS01 CA G 1 D58 N59 E136 Q137 D138 D58 N59 E136 Q137 D138 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 313 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x G 3.0 BS02 CA G 2 E136 Q137 D138 D145 E136 Q137 D138 D145 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 314 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x H 3.0 BS01 CA H 1 D58 N59 E136 Q137 D138 D58 N59 E136 Q137 D138 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 315 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x H 3.0 BS02 CA H 2 E136 D138 Q148 E136 D138 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 316 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x H 3.0 BS03 CPK H 1 N59 Y74 E136 Q148 N59 Y74 E136 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 403 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x I 3.0 BS01 CA I 1 D58 N59 E136 Q137 D138 D58 N59 E136 Q137 D138 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 317 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x I 3.0 BS02 CA I 2 E136 D138 Q148 E136 D138 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 318 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x I 3.0 BS03 CPK I 1 N59 Y74 E136 Q148 N59 Y74 E136 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 -logKd/Ki=6.92, IC50=0.12uM P02743 16036920 401 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x J 3.0 BS01 CPK C 1 N59 Y64 Y74 E136 Q148 N59 Y64 Y74 E136 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 402 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x J 3.0 BS02 CA J 1 D58 N59 E136 Q137 D138 D58 N59 E136 Q137 D138 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 319 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV 2a3x J 3.0 BS03 CA J 2 E136 D138 Q148 E136 D138 Q148 ? 0001849,0002674,0005509,0005515,0005576,0005615,0005634,0006457,0006953,0030246,0042802,0044869,0044871,0045087,0045656,0046597,0046790,0046872,0048525,0051082,0051131,0061045,0062023,0070062,0072562,1903016,1903019 P02743 16036920 320 HTDLSGKVFVFPRESVTDHVNLITPLEKPLQNFTLCFRAYSDLSRAYSLFSYNTQGRDNELLVYKERVGEYSLYIGRHKVTSKVIEKFPAPVHICVSWESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDLYMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV