1ztq A 2.0 BS01 ZN A 1 H197 H201 H207 H116 H120 H126 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 550 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGP 1ztq A 2.0 BS02 ZN A 2 H147 D149 H162 H175 H66 D68 H81 H94 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 551 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGP 1ztq A 2.0 BS03 CA A 1 D154 G155 S157 L159 D177 E180 D73 G74 S76 L78 D96 E99 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 560 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGP 1ztq A 2.0 BS04 CA A 2 D137 N169 G171 D173 D56 N88 G90 D92 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 561 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGP 1ztq A 2.0 BS05 CA A 3 D103 D178 E180 D22 D97 E99 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 562 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGP 1ztq A 2.0 BS06 033 A 1 L159 L160 A161 H197 E198 H201 H207 G212 L214 F216 P217 I218 Y219 T220 F227 P230 L78 L79 A80 H116 E117 H120 H126 G131 L133 F135 P136 I137 Y138 T139 F146 P149 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 ic50=1.3nM -logKd/Ki=8.89, IC50=1.3nM IC50=1.3nM P45452 16005220 601 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGP 1ztq B 2.0 BS01 ZN B 1 H197 H201 H207 H114 H118 H124 H197 E198 H201 H207 H114 E115 H118 H124 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 552 YNVKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGP 1ztq B 2.0 BS02 ZN B 2 H147 D149 H162 H175 H64 D66 H79 H92 H197 E198 H201 H207 H114 E115 H118 H124 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 553 YNVKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGP 1ztq B 2.0 BS03 CA B 1 D154 G155 S157 L159 D177 E180 D71 G72 S74 L76 D94 E97 H197 E198 H201 H207 H114 E115 H118 H124 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 563 YNVKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGP 1ztq B 2.0 BS04 CA B 2 D137 N169 G171 D173 D54 N86 G88 D90 H197 E198 H201 H207 H114 E115 H118 H124 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 564 YNVKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGP 1ztq B 2.0 BS05 CA B 3 D103 D178 E180 D20 D95 E97 H197 E198 H201 H207 H114 E115 H118 H124 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 565 YNVKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGP 1ztq B 2.0 BS06 033 B 1 L159 L160 A161 H197 E198 H207 L214 F216 P217 I218 Y219 T220 L76 L77 A78 H114 E115 H124 L131 F133 P134 I135 Y136 T137 H197 E198 H201 H207 H114 E115 H118 H124 3.4.24.- 0004222,0006508,0008237,0008270,0031012 ic50=1.3nM IC50=1.3nM P45452 16005220 602 YNVKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGP 1ztq C 2.0 BS01 ZN C 1 H197 H201 H207 H116 H120 H126 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 554 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTPDDDVQGIQSLYGP 1ztq C 2.0 BS02 ZN C 2 H147 D149 H162 H175 H66 D68 H81 H94 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 555 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTPDDDVQGIQSLYGP 1ztq C 2.0 BS03 CA C 1 D154 G155 S157 L159 D177 E180 D73 G74 S76 L78 D96 E99 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 566 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTPDDDVQGIQSLYGP 1ztq C 2.0 BS04 CA C 2 D137 N169 G171 D173 D56 N88 G90 D92 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 567 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTPDDDVQGIQSLYGP 1ztq C 2.0 BS05 CA C 3 D103 D178 E180 D22 D97 E99 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 568 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTPDDDVQGIQSLYGP 1ztq C 2.0 BS06 033 C 1 L159 L160 A161 L193 H197 E198 H207 G212 L214 F216 P217 I218 Y219 P230 L78 L79 A80 L112 H116 E117 H126 G131 L133 F135 P136 I137 Y138 P140 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 ic50=1.3nM IC50=1.3nM P45452 16005220 603 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTPDDDVQGIQSLYGP 1ztq D 2.0 BS01 ZN D 1 H197 H201 H207 H116 H120 H126 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 556 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTFMLPDDDVQGIQSLYGP 1ztq D 2.0 BS02 ZN D 2 H147 D149 H162 H175 H66 D68 H81 H94 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 557 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTFMLPDDDVQGIQSLYGP 1ztq D 2.0 BS03 CA D 1 D154 G155 S157 L159 D177 E180 D73 G74 S76 L78 D96 E99 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 569 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTFMLPDDDVQGIQSLYGP 1ztq D 2.0 BS04 CA D 2 D137 N169 G171 D173 D56 N88 G90 D92 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 570 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTFMLPDDDVQGIQSLYGP 1ztq D 2.0 BS05 CA D 3 P102 D103 D178 E180 P21 D22 D97 E99 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 16005220 571 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTFMLPDDDVQGIQSLYGP 1ztq D 2.0 BS06 033 D 1 L159 L160 A161 V194 H197 E198 H207 G212 L214 F216 P217 I218 Y219 F227 L78 L79 A80 V113 H116 E117 H126 G131 L133 F135 P136 I137 Y138 F140 H197 E198 H201 H207 H116 E117 H120 H126 3.4.24.- 0004222,0006508,0008237,0008270,0031012 ic50=1.3nM IC50=1.3nM P45452 16005220 604 YNVFLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTFMLPDDDVQGIQSLYGP