1z4o A 1.9 BS01 MG A 1 D8 D10 D170 D8 D10 D169 D8 L9 D10 T16 K45 S114 A115 K145 E169 D170 D8 L9 D10 T16 K45 S114 A115 K144 E168 D169 5.4.2.6 0000287,0005737,0005975,0008801,0016853,0046872 P71447 15826149 800 MFKAVLFDLDGVITDTAEYHFRAWKALAEEIGINGVDRQFNEQLKGVSREDSLQKILDLADKKVSAEEFKELAKRKNDNYVKMIQDVSPADVYPGILQLLKDLRSNKIKIALASASKNGPFLLERMNLTGYFDAIADPAVAASKPAPDIFIAAAHAVGVAPSESIGLEDSQAGIQAIKDSGALPIGVGRPEDLGDDIVIVPDTSHYTLEFLKEVWLQKQ 1z4o A 1.9 BS02 GL1 A 1 D10 H20 W24 G46 V47 R49 S116 K117 N118 D10 H20 W24 G46 V47 R49 S116 K117 N118 D8 L9 D10 T16 K45 S114 A115 K145 E169 D170 D8 L9 D10 T16 K45 S114 A115 K144 E168 D169 5.4.2.6 0000287,0005737,0005975,0008801,0016853,0046872 Ki=30uM -logKd/Ki=4.52, Ki=30uM P71447 15826149 1220 MFKAVLFDLDGVITDTAEYHFRAWKALAEEIGINGVDRQFNEQLKGVSREDSLQKILDLADKKVSAEEFKELAKRKNDNYVKMIQDVSPADVYPGILQLLKDLRSNKIKIALASASKNGPFLLERMNLTGYFDAIADPAVAASKPAPDIFIAAAHAVGVAPSESIGLEDSQAGIQAIKDSGALPIGVGRPEDLGDDIVIVPDTSHYTLEFLKEVWLQKQ 1z4o B 1.9 BS01 MG B 1 D8 D10 E169 D170 D8 D10 E165 D166 D8 L9 D10 T16 K45 S114 A115 K145 E169 D170 D8 L9 D10 T16 K45 S110 A111 K141 E165 D166 5.4.2.6 0000287,0005737,0005975,0008801,0016853,0046872 P71447 15826149 801 MFKAVLFDLDGVITDTAEYHFRAWKALAEEIGINGVDRQFNEQLKGVSREDSLQKILDLADKEEFKELAKRKNDNYVKMIQDVSPADVYPGILQLLKDLRSNKIKIALASASKNGPFLLERMNLTGYFDAIADPAEVAASKPAPDIFIAAAHAVGVAPSESIGLEDSQAGIQAIKDSGALPIGVGRPEDLGDDIVIVPDTSHYTLEFLKEVWLQK 1z4o B 1.9 BS02 GL1 B 1 H20 W24 G46 V47 R49 A115 S116 K117 N118 H20 W24 G46 V47 R49 A111 S112 K113 N114 D8 L9 D10 T16 K45 S114 A115 K145 E169 D170 D8 L9 D10 T16 K45 S110 A111 K141 E165 D166 5.4.2.6 0000287,0005737,0005975,0008801,0016853,0046872 Ki=30uM P71447 15826149 1221 MFKAVLFDLDGVITDTAEYHFRAWKALAEEIGINGVDRQFNEQLKGVSREDSLQKILDLADKEEFKELAKRKNDNYVKMIQDVSPADVYPGILQLLKDLRSNKIKIALASASKNGPFLLERMNLTGYFDAIADPAEVAASKPAPDIFIAAAHAVGVAPSESIGLEDSQAGIQAIKDSGALPIGVGRPEDLGDDIVIVPDTSHYTLEFLKEVWLQK