1yz0 A 2.07 BS01 F6P A 1 D121 N212 Y215 Y244 G246 S247 M248 Y264 K274 D113 N204 Y207 Y236 G238 S239 M240 Y256 K266 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 15767255 1843 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGILHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1yz0 A 2.07 BS02 MG A 1 E97 D118 D121 E280 E89 D110 D113 E272 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 15767255 655 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGILHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1yz0 A 2.07 BS03 AMP A 1 V17 E20 G21 A24 T27 E29 M30 Y113 R140 M177 V9 E12 G13 A16 T19 E21 M22 Y105 R132 M169 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 Kd=2.4uM IC50=1300nM P00636 15767255 1844 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGILHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1yz0 B 2.07 BS01 F6P B 1 D121 N212 Y215 Y244 G246 M248 Y264 K274 D113 N204 Y207 Y236 G238 M240 Y256 K266 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 15767255 1840 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGILHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1yz0 B 2.07 BS02 MG B 1 E97 D118 D121 E280 E89 D110 D113 E272 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 P00636 15767255 656 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGILHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK 1yz0 B 2.07 BS03 AMP B 1 V17 E20 G21 A24 G26 T27 E29 M30 K112 Y113 R140 M177 V9 E12 G13 A16 G18 T19 E21 M22 K104 Y105 R132 M169 D68 D74 E97 E98 D118 L120 D121 E280 D60 D66 E89 E90 D110 L112 D113 E272 3.1.3.11 0005737,0005829,0005975,0005986,0006000,0006002,0006094,0006111,0016208,0016311,0016787,0016791,0030308,0030388,0042132,0042578,0042802,0045820,0046580,0046872,0048029,0071286,0071466 Kd=2.4uM IC50=1300nM P00636 15767255 1841 NIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGILHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK