1yyr A 2.5 BS01 SAZ A 1 Y93 T96 G186 L187 M221 N225 W298 Y92 T95 G185 L186 M220 N224 W297 Y93 T96 L97 D100 R182 K232 R304 F305 Y92 T95 L96 D99 R181 K231 R303 F304 4.2.3.6 0016106,0016829,0016838,0045482,0046872 P13513 15835903 709 ENFPTEYFLNTTVRLLEYIRYRDSNYTREERIENLHYAYNKAAHHFAQPRQQQLLKVDPKRLQASLQTIVGMVVYSWAKVSKECMADLSIHYTYTLVLDDSKDDPYPTMVNYFDDLQAGREQAHPWWALVNEHFPNVLRHFGPFCSLNLIRSTLDFFEGCWIEQYNFGGFPGSHDYPQFLRRMNGLGHCVGASLWPKEQFNERSLFLEITSAIAQMENWMVWVNDLMSFYKEFDDERDQISLVKNYVVSDEISLHEALEKLTQDTLHSSKQMVAVFSDKDPQVMDTIECFMHGYVTWHLCDRRFRLSEIYEKVKEEKTEDAQKFCKFYEQAANVGAVSPSEWAYPPVAQLANV 1yyr B 2.5 BS01 MG B 1 N225 S229 E233 N223 S227 E231 Y93 T96 L97 D100 R182 K232 R304 F305 Y91 T94 L95 D98 R180 K230 R302 F303 4.2.3.6 0016106,0016829,0016838,0045482,0046872 P13513 15835903 701 NFPTEYFLNTTVRLLEYIRYRDSNYTREERIENLHYAYNKAAHHFAQPRQQQLLKVDPKRLQASLQTIVGMVVYSWAKVSKECMADLSIHYTYTLVLDDSKDDPYPTMVNYFDDLQAGREQAHPWWALVNEHFPNVLRHFGPFCSLNLIRSTLDFFEGCWIEQYNFGGFPGSHDYPQFLRRMNGLGHCVGASLWPKEQFNERSLFLEITSAIAQMENWMVWVNDLMSFYKEFDDERDQISLVKNYVVSDEISLHEALEKLTQDTLHSSKQMVAVFSDKDPQVMDTIECFMHGYVTWHLCDRRFRLSEIYEKVKEEKTEDAQKFCKFYEQAANVGAVSPSEWAYPPVAQLANV 1yyr B 2.5 BS02 SAZ B 1 M73 W78 T96 L97 G186 V191 M221 Y295 M71 W76 T94 L95 G184 V189 M219 Y293 Y93 T96 L97 D100 R182 K232 R304 F305 Y91 T94 L95 D98 R180 K230 R302 F303 4.2.3.6 0016106,0016829,0016838,0045482,0046872 -logKd/Ki=6.29, Ki=0.51uM P13513 15835903 704 NFPTEYFLNTTVRLLEYIRYRDSNYTREERIENLHYAYNKAAHHFAQPRQQQLLKVDPKRLQASLQTIVGMVVYSWAKVSKECMADLSIHYTYTLVLDDSKDDPYPTMVNYFDDLQAGREQAHPWWALVNEHFPNVLRHFGPFCSLNLIRSTLDFFEGCWIEQYNFGGFPGSHDYPQFLRRMNGLGHCVGASLWPKEQFNERSLFLEITSAIAQMENWMVWVNDLMSFYKEFDDERDQISLVKNYVVSDEISLHEALEKLTQDTLHSSKQMVAVFSDKDPQVMDTIECFMHGYVTWHLCDRRFRLSEIYEKVKEEKTEDAQKFCKFYEQAANVGAVSPSEWAYPPVAQLANV 1yyr B 2.5 BS03 POP B 1 D100 R182 N225 S229 K232 E233 R304 F305 D98 R180 N223 S227 K230 E231 R302 F303 Y93 T96 L97 D100 R182 K232 R304 F305 Y91 T94 L95 D98 R180 K230 R302 F303 4.2.3.6 0016106,0016829,0016838,0045482,0046872 P13513 15835903 700 NFPTEYFLNTTVRLLEYIRYRDSNYTREERIENLHYAYNKAAHHFAQPRQQQLLKVDPKRLQASLQTIVGMVVYSWAKVSKECMADLSIHYTYTLVLDDSKDDPYPTMVNYFDDLQAGREQAHPWWALVNEHFPNVLRHFGPFCSLNLIRSTLDFFEGCWIEQYNFGGFPGSHDYPQFLRRMNGLGHCVGASLWPKEQFNERSLFLEITSAIAQMENWMVWVNDLMSFYKEFDDERDQISLVKNYVVSDEISLHEALEKLTQDTLHSSKQMVAVFSDKDPQVMDTIECFMHGYVTWHLCDRRFRLSEIYEKVKEEKTEDAQKFCKFYEQAANVGAVSPSEWAYPPVAQLANV