1yds E 2.2 BS01 peptide I 0 E127 F129 R133 K168 E170 G200 P202 E203 E230 Y235 P236 F239 A240 D241 D328 E113 F115 R119 K154 E156 G186 P188 E189 E216 Y221 P222 F225 A226 D227 D314 N171 D184 N157 D170 2.7.11.11 0001669,0001707,0004672,0004674,0004679,0004691,0005515,0005524,0005634,0005737,0005739,0005829,0005886,0005952,0006468,0010737,0016310,0018105,0019904,0031594,0034237,0034605,0036126,0048471,0106310,1904262 P00517 8824261 5 ~ 24 VKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKDGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF 1yds E 2.2 BS02 IQS E 1 L49 V57 A70 M120 Y122 V123 L173 T183 D184 F327 L35 V43 A56 M106 Y108 V109 L159 T169 D170 F313 N171 D184 N157 D170 2.7.11.11 0001669,0001707,0004672,0004674,0004679,0004691,0005515,0005524,0005634,0005737,0005739,0005829,0005886,0005952,0006468,0010737,0016310,0018105,0019904,0031594,0034237,0034605,0036126,0048471,0106310,1904262 Ki=1.2uM -logKd/Ki=5.92, Ki=1.2uM IC50=5300nM P00517 8824261 351 VKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVMLVKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKDGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF