1yc2 A 2.4 BS01 ZN A 1 C126 C129 C150 C153 C126 C129 C150 C153 P33 T34 F35 R36 N101 D103 H118 P33 T34 F35 R36 N101 D103 H118 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 401 MEDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRSE 1yc2 A 2.4 BS02 ZN A 2 H17 E180 H183 H17 E180 H183 P33 T34 F35 R36 N101 D103 H118 P33 T34 F35 R36 N101 D103 H118 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 402 MEDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRSE 1yc2 A 2.4 BS03 NAD A 1 G23 G25 E29 T34 F35 R36 E38 Q100 G191 S192 S193 N217 A218 E219 K234 A235 G23 G25 E29 T34 F35 R36 E38 Q100 G191 S192 S193 N217 A218 E219 K234 A235 P33 T34 F35 R36 N101 D103 H118 P33 T34 F35 R36 N101 D103 H118 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 503 MEDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRSE 1yc2 A 2.4 BS04 NCA A 1 F35 N101 I102 D103 F35 N101 I102 D103 P33 T34 F35 R36 N101 D103 H118 P33 T34 F35 R36 N101 D103 H118 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 506 MEDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRSE 1yc2 B 2.4 BS01 ZN B 1 C126 C129 C150 C153 C126 C129 C150 C153 P33 T34 F35 R36 N101 D103 H118 P33 T34 F35 R36 N101 D103 H118 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 403 MEDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRSE 1yc2 B 2.4 BS02 ZN B 2 H17 E180 H183 H17 E180 H183 P33 T34 F35 R36 N101 D103 H118 P33 T34 F35 R36 N101 D103 H118 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 404 MEDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRSE 1yc2 B 2.4 BS03 NAD B 1 G23 A24 G25 T34 F35 Q100 N101 I102 D103 G191 S193 N217 A218 E219 K234 A235 G23 A24 G25 T34 F35 Q100 N101 I102 D103 G191 S193 N217 A218 E219 K234 A235 P33 T34 F35 R36 N101 D103 H118 P33 T34 F35 R36 N101 D103 H118 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 501 MEDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRSE 1yc2 B 2.4 BS04 NCA B 1 Q171 Y197 Q171 Y197 P33 T34 F35 R36 N101 D103 H118 P33 T34 F35 R36 N101 D103 H118 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 508 MEDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRSE 1yc2 C 2.4 BS01 ZN C 1 C126 C129 C150 C153 C126 C129 C150 C153 P33 T34 F35 R36 N101 D103 H118 P33 T34 F35 R36 N101 D103 H118 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 405 MEDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRSE 1yc2 C 2.4 BS02 ZN C 2 H17 E180 H183 H17 E180 H183 P33 T34 F35 R36 N101 D103 H118 P33 T34 F35 R36 N101 D103 H118 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 406 MEDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRSE 1yc2 C 2.4 BS03 NAD C 1 G23 A24 G25 E29 F35 R36 Q100 N101 I102 D103 G191 S193 N217 A218 E219 K234 A235 G23 A24 G25 E29 F35 R36 Q100 N101 I102 D103 G191 S193 N217 A218 E219 K234 A235 P33 T34 F35 R36 N101 D103 H118 P33 T34 F35 R36 N101 D103 H118 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 502 MEDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRSE 1yc2 D 2.4 BS01 ZN D 1 C126 C129 C150 C153 C125 C128 C149 C152 P33 T34 F35 R36 N101 D103 H118 P32 T33 F34 R35 N100 D102 H117 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 407 EDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRSE 1yc2 D 2.4 BS02 ZN D 2 H17 E180 H183 H16 E179 H182 P33 T34 F35 R36 N101 D103 H118 P32 T33 F34 R35 N100 D102 H117 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 408 EDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRSE 1yc2 D 2.4 BS03 NAD D 1 G23 A24 G25 A28 E29 F35 R36 E38 Q100 G191 S192 S193 N217 A218 E219 K234 A235 G22 A23 G24 A27 E28 F34 R35 E37 Q99 G190 S191 S192 N216 A217 E218 K233 A234 P33 T34 F35 R36 N101 D103 H118 P32 T33 F34 R35 N100 D102 H117 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 505 EDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRSE 1yc2 D 2.4 BS04 NCA D 1 F35 N101 I102 F34 N100 I101 P33 T34 F35 R36 N101 D103 H118 P32 T33 F34 R35 N100 D102 H117 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 510 EDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRSE 1yc2 E 2.4 BS01 ZN E 1 C126 C129 C150 C153 C126 C129 C150 C153 P33 T34 F35 R36 N101 D103 H118 P33 T34 F35 R36 N101 D103 H118 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 409 MEDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLR 1yc2 E 2.4 BS02 APR E 1 G23 G25 E29 T34 F35 R36 G37 H118 F165 G191 S192 S193 N217 A218 E219 K234 A235 G23 G25 E29 T34 F35 R36 G37 H118 F165 G191 S192 S193 N217 A218 E219 K234 A235 P33 T34 F35 R36 N101 D103 H118 P33 T34 F35 R36 N101 D103 H118 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 504 MEDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLR 1yc2 E 2.4 BS03 NCA E 1 I32 P33 F35 L41 N101 D103 I32 P33 F35 L41 N101 D103 P33 T34 F35 R36 N101 D103 H118 P33 T34 F35 R36 N101 D103 H118 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 507 MEDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLR 1yc2 E 2.4 BS04 NCA E 2 E131 R151 K152 E131 R151 K152 P33 T34 F35 R36 N101 D103 H118 P33 T34 F35 R36 N101 D103 H118 2.3.1.286 0005737,0006338,0006476,0008270,0016740,0017136,0034979,0036049,0036054,0036055,0046872,0051287,0070403 O30124 15780941 509 MEDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLR