1xjb A 1.9 BS01 ACT A 1 P17 L19 F284 P19 L21 F286 D50 Y55 K84 H117 D52 Y57 K86 H119 1.-.-.-,1.1.1.112,1.1.1.209,1.1.1.357,1.1.1.53,1.1.1.62,1.3.1.20 0004032,0004303,0005737,0005829,0006693,0007186,0007586,0008202,0008284,0016491,0016655,0030855,0031406,0032052,0042448,0044597,0044598,0047023,0047044,0047086,0047115,0047718,0051897,0071395,0071799 P52895 15929998 1002 SVDDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY 1xjb A 1.9 BS02 ACT A 2 Y55 H117 Y57 H119 D50 Y55 K84 H117 D52 Y57 K86 H119 1.-.-.-,1.1.1.112,1.1.1.209,1.1.1.357,1.1.1.53,1.1.1.62,1.3.1.20 0004032,0004303,0005737,0005829,0006693,0007186,0007586,0008202,0008284,0016491,0016655,0030855,0031406,0032052,0042448,0044597,0044598,0047023,0047044,0047086,0047115,0047718,0051897,0071395,0071799 P52895 15929998 5002 SVDDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY 1xjb A 1.9 BS03 NAP A 1 G22 T23 Y24 D50 Y55 H117 N167 Q190 Y216 S217 L219 S221 H222 L236 A253 L268 A269 K270 S271 R276 Q279 N280 G24 T25 Y26 D52 Y57 H119 N169 Q192 Y218 S219 L221 S223 H224 L238 A255 L270 A271 K272 S273 R278 Q281 N282 D50 Y55 K84 H117 D52 Y57 K86 H119 1.-.-.-,1.1.1.112,1.1.1.209,1.1.1.357,1.1.1.53,1.1.1.62,1.3.1.20 0004032,0004303,0005737,0005829,0006693,0007186,0007586,0008202,0008284,0016491,0016655,0030855,0031406,0032052,0042448,0044597,0044598,0047023,0047044,0047086,0047115,0047718,0051897,0071395,0071799 Kd=0.88uM P52895 15929998 1001 SVDDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY 1xjb B 1.9 BS01 ACT B 1 Y55 H117 Y54 H116 D50 Y55 K84 H117 D49 Y54 K83 H116 1.-.-.-,1.1.1.112,1.1.1.209,1.1.1.357,1.1.1.53,1.1.1.62,1.3.1.20 0004032,0004303,0005737,0005829,0006693,0007186,0007586,0008202,0008284,0016491,0016655,0030855,0031406,0032052,0042448,0044597,0044598,0047023,0047044,0047086,0047115,0047718,0051897,0071395,0071799 P52895 15929998 6002 DSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY 1xjb B 1.9 BS02 NAP B 1 G22 T23 Y24 D50 Y55 H117 Q190 Y216 S217 L219 S221 H222 L236 A253 L268 K270 S271 R276 Q279 N280 L306 G21 T22 Y23 D49 Y54 H116 Q189 Y215 S216 L218 S220 H221 L235 A252 L267 K269 S270 R275 Q278 N279 L305 D50 Y55 K84 H117 D49 Y54 K83 H116 1.-.-.-,1.1.1.112,1.1.1.209,1.1.1.357,1.1.1.53,1.1.1.62,1.3.1.20 0004032,0004303,0005737,0005829,0006693,0007186,0007586,0008202,0008284,0016491,0016655,0030855,0031406,0032052,0042448,0044597,0044598,0047023,0047044,0047086,0047115,0047718,0051897,0071395,0071799 Kd=0.88uM P52895 15929998 5001 DSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY