1x78 A 2.3 BS01 peptide C 0 I310 K314 D489 L490 E493 I48 K52 D217 L218 E221 ? 0003677,0004879,0006355 Q92731 15548008 605 ~ 613 LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVL 1x78 A 2.3 BS02 244 A 1 M295 L298 L301 E305 L339 I376 F377 H475 L476 M33 L36 L39 E43 L77 I114 F115 H203 L204 ? 0003677,0004879,0006355 ic50=14nM -logKd/Ki=7.85, IC50=14.0nM IC50=14nM Q92731 15548008 201 LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVL 1x78 B 2.3 BS01 peptide D 0 I310 K314 E493 I48 K52 E221 ? 0003677,0004879,0006355 Q92731 15548008 605 ~ 613 LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVL 1x78 B 2.3 BS02 244 B 1 E305 L339 I376 F377 G472 H475 L476 E43 L77 I114 F115 G200 H203 L204 ? 0003677,0004879,0006355 ic50=14nM IC50=14nM Q92731 15548008 202 LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVL