1wun H 2.4 BS01 CA H 1 E70 D72 E75 E80 E58 D60 E63 E68 3.4.21.21 0004252,0006508 P08709 15629154 1001 IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP 1wun H 2.4 BS02 P5B H 1 H57 D60 G97 T98 S170H P170I D189 S190 C191 K192 S195 S214 W215 G216 Q217 G219 H41 D44 G85 T86 S168 P169 D186 S187 C188 K189 S192 S211 W212 G213 Q214 G215 3.4.21.21 0004252,0006508 ic50=62nM -logKd/Ki=7.21, IC50=62nM P08709 15629154 2001 IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP 1wun L 2.4 BS01 BGC L 1 Q49 S52 Q49 S52 3.4.21.21 0005509,0005576 P08709 15629154 1052 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 1wun L 2.4 BS02 FUC L 1 G58 S60 C72 L73 G58 S60 C72 L73 3.4.21.21 0005509,0005576 P08709 15629154 1060 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 1wun L 2.4 BS03 CA L 1 D46 G47 Q49 D63 Q64 D46 G47 Q49 D63 Q64 3.4.21.21 0005509,0005576 P08709 15629154 1002 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 1wun L 2.4 BS04 CA L 2 E7 E26 E29 E7 E26 E29 3.4.21.21 0005509,0005576 P08709 15629154 1003 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 1wun L 2.4 BS05 CA L 3 E7 E16 E26 E29 E7 E16 E26 E29 3.4.21.21 0005509,0005576 P08709 15629154 1004 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 1wun L 2.4 BS06 CA L 4 A1 N2 E6 E7 E16 E26 A1 N2 E6 E7 E16 E26 3.4.21.21 0005509,0005576 P08709 15629154 1005 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 1wun L 2.4 BS07 CA L 5 A1 E6 E16 E20 A1 E6 E16 E20 3.4.21.21 0005509,0005576 P08709 15629154 1006 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 1wun L 2.4 BS08 CA L 6 E14 E19 E14 E19 3.4.21.21 0005509,0005576 P08709 15629154 1007 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 1wun L 2.4 BS09 CA L 7 E25 E29 E25 E29 3.4.21.21 0005509,0005576 P08709 15629154 1009 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE