1wqv H 2.5 BS01 CA H 1 E70 D72 E75 E80 E58 D60 E63 E68 3.4.21.21 0004252,0006508 P08709 15504346 501 IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP 1wqv H 2.5 BS02 PSM H 1 H57 T98 T99 D189 S190 C191 K192 S195 V213 S214 W215 G216 G219 H41 T86 T87 D186 S187 C188 K189 S192 V210 S211 W212 G213 G215 3.4.21.21 0004252,0006508 ic50=130nM -logKd/Ki=6.89, IC50=130nM P08709 15504346 1001 IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP 1wqv L 2.5 BS01 BGC L 1 Q49 S52 Y68 Q49 S52 Y68 3.4.21.21 0005509,0005576 P08709 15504346 1052 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 1wqv L 2.5 BS02 FUC L 1 S60 F71 C72 S60 F71 C72 3.4.21.21 0005509,0005576 P08709 15504346 1060 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 1wqv L 2.5 BS03 CA L 1 D46 G47 Q49 D63 Q64 D46 G47 Q49 D63 Q64 3.4.21.21 0005509,0005576 P08709 15504346 502 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 1wqv L 2.5 BS04 CA L 2 E7 E26 E29 E7 E26 E29 3.4.21.21 0005509,0005576 P08709 15504346 503 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 1wqv L 2.5 BS05 CA L 3 E7 E16 E26 E29 E7 E16 E26 E29 3.4.21.21 0005509,0005576 P08709 15504346 504 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 1wqv L 2.5 BS06 CA L 4 A1 N2 E6 E7 E16 E26 A1 N2 E6 E7 E16 E26 3.4.21.21 0005509,0005576 P08709 15504346 505 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 1wqv L 2.5 BS07 CA L 5 A1 E6 E16 E20 A1 E6 E16 E20 3.4.21.21 0005509,0005576 P08709 15504346 506 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 1wqv L 2.5 BS08 CA L 6 E14 E19 E14 E19 3.4.21.21 0005509,0005576 P08709 15504346 507 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE 1wqv L 2.5 BS09 CA L 7 E25 E29 E25 E29 3.4.21.21 0005509,0005576 P08709 15504346 509 ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE