1v1j A 2.2 BS01 FA3 A 1 Y28 N79 A81 A82 H85 H106 I107 S108 R117 Y28 N79 A81 A82 H85 H106 I107 S108 R117 P15 N16 R23 Y28 N79 A82 E104 H106 R113 P15 N16 R23 Y28 N79 A82 E104 H106 R113 4.2.1.10 0003855,0008652,0009073,0009423,0016829,0019631 Ki=15uM -logKd/Ki=4.82, Ki=15uM P15474 15162210 201 PRSLANAPIMILNGPNLNLLGQRQPEIYGSDTLADVEALCVKAAAAHGGTVDFRQSNHEGELVDWIHEARLNHCGIVINPAAYSHTSVAILDALNTCDGLPVVEVHISNIHQREPFRHHSYVSQRADGVVAGCGVQGYVFGVERIAALAG 1v1j B 2.2 BS01 FA3 B 1 Y28 N79 A81 A82 H85 H106 I107 S108 R117 Y28 N79 A81 A82 H85 H106 I107 S108 R117 P15 N16 R23 Y28 N79 A82 E104 H106 R113 P15 N16 R23 Y28 N79 A82 E104 H106 R113 4.2.1.10 0003855,0008652,0009073,0009423,0016829,0019631 Ki=15uM -logKd/Ki=4.82, Ki=15uM P15474 15162210 201 PRSLANAPIMILNGPNLNLLGQRQPEIYGSDTLADVEALCVKAAAAHGGTVDFRQSNHEGELVDWIHEARLNHCGIVINPAAYSHTSVAILDALNTCDGLPVVEVHISNIHQREPFRHHSYVSQRADGVVAGCGVQGYVFGVERIAALAG 1v1j C 2.2 BS01 FA3 C 1 Y28 N79 A81 A82 H85 H106 I107 S108 R117 Y28 N79 A81 A82 H85 H106 I107 S108 R117 P15 N16 R23 Y28 N79 A82 E104 H106 R113 P15 N16 R23 Y28 N79 A82 E104 H106 R113 4.2.1.10 0003855,0008652,0009073,0009423,0016829,0019631 Ki=15uM P15474 15162210 201 PRSLANAPIMILNGPNLNLLGQRQPEIYGSDTLADVEALCVKAAAAHGGTVDFRQSNHEGELVDWIHEARLNHCGIVINPAAYSHTSVAILDALNTCDGLPVVEVHISNIHQREPFRHHSYVSQRADGVVAGCGVQGYVFGVERIAALAG 1v1j D 2.2 BS01 FA3 D 1 Y28 N79 A81 A82 H85 H106 I107 S108 R117 Y28 N79 A81 A82 H85 H106 I107 S108 R117 P15 N16 R23 Y28 N79 A82 E104 H106 R113 P15 N16 R23 Y28 N79 A82 E104 H106 R113 4.2.1.10 0003855,0008652,0009073,0009423,0016829,0019631 Ki=15uM P15474 15162210 201 PRSLANAPIMILNGPNLNLLGQRQPEIYGSDTLADVEALCVKAAAAHGGTVDFRQSNHEGELVDWIHEARLNHCGIVINPAAYSHTSVAILDALNTCDGLPVVEVHISNIHQREPFRHHSYVSQRADGVVAGCGVQGYVFGVERIAALAG 1v1j E 2.2 BS01 FA3 E 1 Y28 N79 A81 A82 H85 H106 I107 S108 R117 Y28 N79 A81 A82 H85 H106 I107 S108 R117 P15 N16 R23 Y28 N79 A82 E104 H106 R113 P15 N16 R23 Y28 N79 A82 E104 H106 R113 4.2.1.10 0003855,0008652,0009073,0009423,0016829,0019631 Ki=15uM P15474 15162210 201 PRSLANAPIMILNGPNLNLLGQRQPEIYGSDTLADVEALCVKAAAAHGGTVDFRQSNHEGELVDWIHEARLNHCGIVINPAAYSHTSVAILDALNTCDGLPVVEVHISNIHQREPFRHHSYVSQRADGVVAGCGVQGYVFGVERIAALAG 1v1j F 2.2 BS01 FA3 F 1 Y28 N79 A81 A82 H85 H106 I107 S108 R117 Y28 N79 A81 A82 H85 H106 I107 S108 R117 P15 N16 R23 Y28 N79 A82 E104 H106 R113 P15 N16 R23 Y28 N79 A82 E104 H106 R113 4.2.1.10 0003855,0008652,0009073,0009423,0016829,0019631 Ki=15uM P15474 15162210 201 PRSLANAPIMILNGPNLNLLGQRQPEIYGSDTLADVEALCVKAAAAHGGTVDFRQSNHEGELVDWIHEARLNHCGIVINPAAYSHTSVAILDALNTCDGLPVVEVHISNIHQREPFRHHSYVSQRADGVVAGCGVQGYVFGVERIAALAG 1v1j G 2.2 BS01 FA3 G 1 Y28 N79 A81 A82 H85 H106 I107 S108 R117 Y28 N79 A81 A82 H85 H106 I107 S108 R117 P15 N16 R23 Y28 N79 A82 E104 H106 R113 P15 N16 R23 Y28 N79 A82 E104 H106 R113 4.2.1.10 0003855,0008652,0009073,0009423,0016829,0019631 Ki=15uM P15474 15162210 201 PRSLANAPIMILNGPNLNLLGQRQPEIYGSDTLADVEALCVKAAAAHGGTVDFRQSNHEGELVDWIHEARLNHCGIVINPAAYSHTSVAILDALNTCDGLPVVEVHISNIHQREPFRHHSYVSQRADGVVAGCGVQGYVFGVERIAALAG 1v1j H 2.2 BS01 FA3 H 1 Y28 N79 A81 A82 H85 H106 I107 S108 R117 Y28 N79 A81 A82 H85 H106 I107 S108 R117 P15 N16 R23 Y28 N79 A82 E104 H106 R113 P15 N16 R23 Y28 N79 A82 E104 H106 R113 4.2.1.10 0003855,0008652,0009073,0009423,0016829,0019631 Ki=15uM P15474 15162210 201 PRSLANAPIMILNGPNLNLLGQRQPEIYGSDTLADVEALCVKAAAAHGGTVDFRQSNHEGELVDWIHEARLNHCGIVINPAAYSHTSVAILDALNTCDGLPVVEVHISNIHQREPFRHHSYVSQRADGVVAGCGVQGYVFGVERIAALAG 1v1j I 2.2 BS01 FA3 I 1 Y28 N79 A81 A82 H85 H106 I107 S108 R117 Y28 N79 A81 A82 H85 H106 I107 S108 R117 P15 N16 R23 Y28 N79 A82 E104 H106 R113 P15 N16 R23 Y28 N79 A82 E104 H106 R113 4.2.1.10 0003855,0008652,0009073,0009423,0016829,0019631 Ki=15uM P15474 15162210 201 PRSLANAPIMILNGPNLNLLGQRQPEIYGSDTLADVEALCVKAAAAHGGTVDFRQSNHEGELVDWIHEARLNHCGIVINPAAYSHTSVAILDALNTCDGLPVVEVHISNIHQREPFRHHSYVSQRADGVVAGCGVQGYVFGVERIAALAG 1v1j J 2.2 BS01 FA3 J 1 Y28 N79 A81 A82 H85 H106 I107 S108 R117 Y28 N79 A81 A82 H85 H106 I107 S108 R117 P15 N16 R23 Y28 N79 A82 E104 H106 R113 P15 N16 R23 Y28 N79 A82 E104 H106 R113 4.2.1.10 0003855,0008652,0009073,0009423,0016829,0019631 Ki=15uM P15474 15162210 201 PRSLANAPIMILNGPNLNLLGQRQPEIYGSDTLADVEALCVKAAAAHGGTVDFRQSNHEGELVDWIHEARLNHCGIVINPAAYSHTSVAILDALNTCDGLPVVEVHISNIHQREPFRHHSYVSQRADGVVAGCGVQGYVFGVERIAALAG 1v1j K 2.2 BS01 FA3 K 1 Y28 N79 A81 A82 H85 H106 I107 S108 R117 Y28 N79 A81 A82 H85 H106 I107 S108 R117 P15 N16 R23 Y28 N79 A82 E104 H106 R113 P15 N16 R23 Y28 N79 A82 E104 H106 R113 4.2.1.10 0003855,0008652,0009073,0009423,0016829,0019631 Ki=15uM P15474 15162210 201 PRSLANAPIMILNGPNLNLLGQRQPEIYGSDTLADVEALCVKAAAAHGGTVDFRQSNHEGELVDWIHEARLNHCGIVINPAAYSHTSVAILDALNTCDGLPVVEVHISNIHQREPFRHHSYVSQRADGVVAGCGVQGYVFGVERIAALAG 1v1j L 2.2 BS01 FA3 L 1 Y28 N79 A81 A82 H85 H106 I107 S108 R117 Y28 N79 A81 A82 H85 H106 I107 S108 R117 P15 N16 R23 Y28 N79 A82 E104 H106 R113 P15 N16 R23 Y28 N79 A82 E104 H106 R113 4.2.1.10 0003855,0008652,0009073,0009423,0016829,0019631 Ki=15uM P15474 15162210 201 PRSLANAPIMILNGPNLNLLGQRQPEIYGSDTLADVEALCVKAAAAHGGTVDFRQSNHEGELVDWIHEARLNHCGIVINPAAYSHTSVAILDALNTCDGLPVVEVHISNIHQREPFRHHSYVSQRADGVVAGCGVQGYVFGVERIAALAG