1upf A 2.3 BS01 URF A 1 M166 Y228 M146 Y208 R137 T141 D235 D238 R117 T121 D215 D218 2.4.2.9 0004845,0005525,0005737,0016757,0044206 Ki=25uM -logKd/Ki=4.60, Ki=25uM Q26998 9628859 999 QEESILQDIITRFPNVVLMKQTAQLRAMMTIIRDKETPKEEFVFYADRLIRLLIEEALNELPFQKKEVTTPLDVSYHGVSFYSKICGVSIVRAGESMESGLRAVCRGVRIGKILIQRDETTAEPKLIYEKLPADIRERWVMLLDPMCATAGSVCKAIEVLLRLGVKEERIIFVNILAAPQGIERVFKEYPKVRMVTAAVDICLNSRYYIVPGIGDFGDRYFGTM 1upf B 2.3 BS01 URF B 1 M166 Y228 I229 G234 D235 F236 M146 Y208 I209 G214 D215 F216 R137 T141 D235 D238 R117 T121 D215 D218 2.4.2.9 0004845,0005525,0005737,0016757,0044206 Ki=25uM Q26998 9628859 999 QEESILQDIITRFPNVVLMKQTAQLRAMMTIIRDKETPKEEFVFYADRLIRLLIEEALNELPFQKKEVTTPLDVSYHGVSFYSKICGVSIVRAGESMESGLRAVCRGVRIGKILIQRDETTAEPKLIYEKLPADIRERWVMLLDPMCATAGSVCKAIEVLLRLGVKEERIIFVNILAAPQGIERVFKEYPKVRMVTAAVDICLNSRYYIVPGIGDFGDRYFGTM 1upf C 2.3 BS01 URF C 1 M166 Y228 I229 G234 D235 M146 Y208 I209 G214 D215 R137 T141 D235 D238 R117 T121 D215 D218 2.4.2.9 0004845,0005525,0005737,0016757,0044206 Ki=25uM Q26998 9628859 999 QEESILQDIITRFPNVVLMKQTAQLRAMMTIIRDKETPKEEFVFYADRLIRLLIEEALNELPFQKKEVTTPLDVSYHGVSFYSKICGVSIVRAGESMESGLRAVCRGVRIGKILIQRDETTAEPKLIYEKLPADIRERWVMLLDPMCATAGSVCKAIEVLLRLGVKEERIIFVNILAAPQGIERVFKEYPKVRMVTAAVDICLNSRYYIVPGIGDFGDRYFGTM 1upf D 2.3 BS01 URF D 1 M166 A168 Y227 Y228 I229 M146 A148 Y207 Y208 I209 R137 T141 D235 D238 R117 T121 D215 D218 2.4.2.9 0004845,0005525,0005737,0016757,0044206 Ki=25uM -logKd/Ki=4.60, Ki=25uM Q26998 9628859 999 QEESILQDIITRFPNVVLMKQTAQLRAMMTIIRDKETPKEEFVFYADRLIRLLIEEALNELPFQKKEVTTPLDVSYHGVSFYSKICGVSIVRAGESMESGLRAVCRGVRIGKILIQRDETTAEPKLIYEKLPADIRERWVMLLDPMCATAGSVCKAIEVLLRLGVKEERIIFVNILAAPQGIERVFKEYPKVRMVTAAVDICLNSRYYIVPGIGDFGDRYFGTM