1u3u A 1.6 BS01 ZN A 1 C97 C100 C103 C111 C97 C100 C103 C111 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.105 0001523,0004022,0004745,0005515,0005654,0005737,0005829,0005886,0006629,0008270,0016491,0042572,0042573,0046872 P00325 15449945 375 STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF 1u3u A 1.6 BS02 ZN A 2 C46 H67 C174 C46 H67 C174 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.105 0001523,0004022,0004745,0005515,0005654,0005737,0005829,0005886,0006629,0008270,0016491,0042572,0042573,0046872 P00325 15449945 376 STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF 1u3u A 1.6 BS03 NAD A 1 R47 T48 H51 C174 T178 G199 L200 G201 V203 D223 I224 K228 V268 I269 R271 V292 G293 V294 V318 R369 R47 T48 H51 C174 T178 G199 L200 G201 V203 D223 I224 K228 V268 I269 R271 V292 G293 V294 V318 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.105 0001523,0004022,0004745,0005515,0005654,0005737,0005829,0005886,0006629,0008270,0016491,0042572,0042573,0046872 P00325 15449945 1377 STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF 1u3u A 1.6 BS04 BNF A 1 T48 H67 F93 C174 V294 T48 H67 F93 C174 V294 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.105 0001523,0004022,0004745,0005515,0005654,0005737,0005829,0005886,0006629,0008270,0016491,0042572,0042573,0046872 Ki=0.33uM Ki=330nM P00325 15449945 1378 STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF 1u3u B 1.6 BS01 ZN B 1 C97 C100 C103 C111 C97 C100 C103 C111 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.105 0001523,0004022,0004745,0005515,0005654,0005737,0005829,0005886,0006629,0008270,0016491,0042572,0042573,0046872 P00325 15449945 375 STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF 1u3u B 1.6 BS02 ZN B 2 C46 H67 C174 C46 H67 C174 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.105 0001523,0004022,0004745,0005515,0005654,0005737,0005829,0005886,0006629,0008270,0016491,0042572,0042573,0046872 P00325 15449945 376 STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF 1u3u B 1.6 BS03 NAD B 1 C46 R47 T48 H51 C174 T178 L200 G201 V203 D223 I224 K228 V268 I269 R271 V292 G293 V294 V318 R369 C46 R47 T48 H51 C174 T178 L200 G201 V203 D223 I224 K228 V268 I269 R271 V292 G293 V294 V318 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.105 0001523,0004022,0004745,0005515,0005654,0005737,0005829,0005886,0006629,0008270,0016491,0042572,0042573,0046872 P00325 15449945 2377 STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF 1u3u B 1.6 BS04 BNF B 1 T48 H67 F93 L116 C174 V294 T48 H67 F93 L116 C174 V294 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 C46 R47 T48 H51 H67 E68 C97 C100 C103 C111 D115 C174 T178 R369 1.1.1.105 0001523,0004022,0004745,0005515,0005654,0005737,0005829,0005886,0006629,0008270,0016491,0042572,0042573,0046872 Ki=0.33uM Ki=330nM P00325 15449945 2378 STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF