1tw8 A 2.8 BS01 dna E 0 H31 Y77 G92 K93 Q109 Q138 Y199 N201 A204 K248 H30 Y76 G91 K92 Q108 Q137 Y198 N200 A203 K247 3.1.21.4 0003677,0004519,0009036,0009307 Kd=1.14nM P17743 15491133 1 ~ 13 SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYIL 1tw8 A 2.8 BS02 dna F 0 G30 H31 Q109 N110 D114 D127 K129 T130 N132 S136 A137 Q138 N141 S144 Y146 K147 Q207 G29 H30 Q108 N109 D113 D126 K128 T129 N131 S135 A136 Q137 N140 S143 Y145 K146 Q206 3.1.21.4 0003677,0004519,0009036,0009307 Kd=1.14nM P17743 15491133 1 ~ 13 SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYIL 1tw8 A 2.8 BS03 CA A 1 D114 D127 V128 D113 D126 V127 3.1.21.4 0003677,0004519,0009036,0009307 P17743 15491133 801 SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYIL 1tw8 A 2.8 BS04 NA A 1 D127 K129 I142 I143 D126 K128 I141 I142 3.1.21.4 0003677,0004519,0009036,0009307 P17743 15491133 901 SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYIL 1tw8 B 2.8 BS01 dna E 0 G30 H31 Q109 N110 D114 D127 T130 R131 S136 A137 Q138 A139 P140 N141 S144 Y146 K147 Q207 G29 H30 Q108 N109 D113 D126 T129 R130 S135 A136 Q137 A138 P139 N140 S143 Y145 K146 Q206 3.1.21.4 0003677,0004519,0009036,0009307 Kd=1.14nM P17743 15491133 1 ~ 13 SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYI 1tw8 B 2.8 BS02 dna F 0 Y77 S90 K93 K108 Q109 Q138 Y199 N201 A203 A204 R241 K248 Y76 S89 K92 K107 Q108 Q137 Y198 N200 A202 A203 R240 K247 3.1.21.4 0003677,0004519,0009036,0009307 Kd=1.14nM P17743 15491133 1 ~ 13 SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYI 1tw8 B 2.8 BS03 CA B 1 D114 D127 V128 D113 D126 V127 3.1.21.4 0003677,0004519,0009036,0009307 P17743 15491133 802 SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYI 1tw8 B 2.8 BS04 NA B 1 D127 I142 I143 D126 I141 I142 3.1.21.4 0003677,0004519,0009036,0009307 P17743 15491133 902 SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYI 1tw8 C 2.8 BS01 dna G 0 H31 Y77 K93 K108 Q109 Q138 Y199 N201 Q209 R241 K248 H30 Y76 K92 K107 Q108 Q137 Y198 N200 Q208 R240 K247 3.1.21.4 0003677,0004519,0009036,0009307 Kd=1.14nM P17743 15491133 1 ~ 13 SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYIL 1tw8 C 2.8 BS02 dna H 0 G30 H31 Q109 N110 D111 D114 K135 A137 Q138 A139 P140 N141 S144 Y146 K147 A205 M206 Q207 G29 H30 Q108 N109 D110 D113 K134 A136 Q137 A138 P139 N140 S143 Y145 K146 A204 M205 Q206 3.1.21.4 0003677,0004519,0009036,0009307 Kd=1.14nM P17743 15491133 1 ~ 13 SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYIL 1tw8 C 2.8 BS03 CA C 1 D114 D127 V128 D113 D126 V127 3.1.21.4 0003677,0004519,0009036,0009307 P17743 15491133 803 SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYIL 1tw8 C 2.8 BS04 NA C 1 D127 N141 I142 I143 D126 N140 I141 I142 3.1.21.4 0003677,0004519,0009036,0009307 P17743 15491133 903 SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKYIL 1tw8 D 2.8 BS01 dna G 0 G30 H31 Q109 N110 D114 K129 T130 N132 S136 Q138 P140 N141 I143 S144 K147 Q207 G29 H30 Q108 N109 D113 K128 T129 N131 S135 Q137 P139 N140 I142 S143 K146 Q206 3.1.21.4 0003677,0004519,0009036,0009307 Kd=1.14nM P17743 15491133 1 ~ 13 SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKY 1tw8 D 2.8 BS02 dna H 0 H31 Y77 S90 G92 K93 Q109 Q138 Y199 N201 A203 A204 R241 H30 Y76 S89 G91 K92 Q108 Q137 Y198 N200 A202 A203 R240 3.1.21.4 0003677,0004519,0009036,0009307 Kd=1.14nM P17743 15491133 1 ~ 13 SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKY 1tw8 D 2.8 BS03 CA D 1 D114 D127 V128 D113 D126 V127 3.1.21.4 0003677,0004519,0009036,0009307 P17743 15491133 804 SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKY 1tw8 D 2.8 BS04 NA D 1 D127 K129 I142 D126 K128 I141 3.1.21.4 0003677,0004519,0009036,0009307 P17743 15491133 904 SFIKPIYQDINSILIGQKVKRPKSGTLSGHAAGEPFEKLVYKFLKENLSDLTFKQYEYLNDLFMKNPAIIGHEARYKLFNSPTLLFLLSRGKAATENWSIENLFEEKQNDTADILLVKDQFYELLDVKTRNISKSAQAPNIISAYKLAQTCAKMIDNKEFDLFDINYLEVDWELNGEDLVCVSTSFAELFKSEPSELYINWAAAMQIQFHVRDLDQGFNGTREEWAKSYLKHFVTQAEQRAISMIDKFVKPFKKY