1t31 A 1.9 BS01 CO A 1 H25 E78 H10 E64 H57 D102 K192 G193 D194 S195 G196 H45 D89 K179 G180 D181 S182 G183 3.4.21.39 0002003,0004175,0004252,0005576,0005615,0005737,0005829,0006508,0006518,0008236,0016485,0022617,0030141,0030163,0030901,0034769,0036464,0042277,0043231,0045766,0050727,0062023,0071333,0140447 P23946 15741158 909 IIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQKNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGAAQGIVSYGRSDAKPPAVFTRISHYQPWINQILQAN 1t31 A 1.9 BS02 OHH A 1 K40 H57 A190 F191 K192 G193 S195 S214 Y215 G216 R217 A226 K28 H45 A177 F178 K179 G180 S182 S197 Y198 G199 R200 A207 H57 D102 K192 G193 D194 S195 G196 H45 D89 K179 G180 D181 S182 G183 3.4.21.39 0002003,0004175,0004252,0005576,0005615,0005737,0005829,0006508,0006518,0008236,0016485,0022617,0030141,0030163,0030901,0034769,0036464,0042277,0043231,0045766,0050727,0062023,0071333,0140447 Ki=2.3nM -logKd/Ki=8.64, Ki=2.3nM Ki=2.3nM, IC50=4.5nM P23946 15741158 901 IIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQKNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGAAQGIVSYGRSDAKPPAVFTRISHYQPWINQILQAN