1t2f A 3.0 BS01 NAD A 1 G29 V31 D52 V53 L54 Y83 T95 G97 V98 R99 I120 V136 S137 N138 H193 T248 I252 G29 V31 D52 V53 L54 Y83 T95 G97 V98 R99 I120 V136 S137 N138 H193 T248 I252 R106 D166 R169 H193 S196 R106 D166 R169 H193 S196 1.1.1.27 0003824,0004457,0004459,0005515,0005737,0005739,0005743,0005829,0006089,0006090,0016020,0016491,0016616,0019674,0019752,0019900,0042802,0045121,0051287,0070062,1990204 P07195 15117937 401 ATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKF 1t2f A 3.0 BS02 OXQ A 1 Q100 R106 N138 L165 R169 H193 A238 T248 Q100 R106 N138 L165 R169 H193 A238 T248 R106 D166 R169 H193 S196 R106 D166 R169 H193 S196 1.1.1.27 0003824,0004457,0004459,0005515,0005737,0005739,0005743,0005829,0006089,0006090,0016020,0016491,0016616,0019674,0019752,0019900,0042802,0045121,0051287,0070062,1990204 IC50=72050nM P07195 15117937 402 ATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKF 1t2f B 3.0 BS01 NAD B 1 G29 Q30 V31 D52 V53 L54 T95 A96 G97 V98 R99 I120 V136 S137 N138 H193 I252 G29 Q30 V31 D52 V53 L54 T95 A96 G97 V98 R99 I120 V136 S137 N138 H193 I252 R106 D166 R169 H193 S196 R106 D166 R169 H193 S196 1.1.1.27 0003824,0004457,0004459,0005515,0005737,0005739,0005743,0005829,0006089,0006090,0016020,0016491,0016616,0019674,0019752,0019900,0042802,0045121,0051287,0070062,1990204 P07195 15117937 403 ATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKF 1t2f B 3.0 BS02 OXQ B 1 Q100 R106 N138 R169 H193 T248 Q100 R106 N138 R169 H193 T248 R106 D166 R169 H193 S196 R106 D166 R169 H193 S196 1.1.1.27 0003824,0004457,0004459,0005515,0005737,0005739,0005743,0005829,0006089,0006090,0016020,0016491,0016616,0019674,0019752,0019900,0042802,0045121,0051287,0070062,1990204 IC50=72050nM P07195 15117937 404 ATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKF 1t2f C 3.0 BS01 NAD C 1 G29 Q30 V31 D52 V53 L54 T95 A96 G97 V98 R99 V136 N138 H193 I252 G29 Q30 V31 D52 V53 L54 T95 A96 G97 V98 R99 V136 N138 H193 I252 R106 D166 R169 H193 S196 R106 D166 R169 H193 S196 1.1.1.27 0003824,0004457,0004459,0005515,0005737,0005739,0005743,0005829,0006089,0006090,0016020,0016491,0016616,0019674,0019752,0019900,0042802,0045121,0051287,0070062,1990204 P07195 15117937 405 ATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKF 1t2f C 3.0 BS02 OXQ C 1 Q100 R106 N138 R169 H193 A238 T248 Q100 R106 N138 R169 H193 A238 T248 R106 D166 R169 H193 S196 R106 D166 R169 H193 S196 1.1.1.27 0003824,0004457,0004459,0005515,0005737,0005739,0005743,0005829,0006089,0006090,0016020,0016491,0016616,0019674,0019752,0019900,0042802,0045121,0051287,0070062,1990204 IC50=72050nM P07195 15117937 406 ATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKF 1t2f D 3.0 BS01 NAD D 1 G29 Q30 V31 D52 V53 L54 T95 A96 G97 V98 R99 V136 H193 T248 I252 G29 Q30 V31 D52 V53 L54 T95 A96 G97 V98 R99 V136 H193 T248 I252 R106 D166 R169 H193 S196 R106 D166 R169 H193 S196 1.1.1.27 0003824,0004457,0004459,0005515,0005737,0005739,0005743,0005829,0006089,0006090,0016020,0016491,0016616,0019674,0019752,0019900,0042802,0045121,0051287,0070062,1990204 P07195 15117937 407 ATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKF 1t2f D 3.0 BS02 OXQ D 1 Q100 R106 N138 R169 H193 A238 T248 Q100 R106 N138 R169 H193 A238 T248 R106 D166 R169 H193 S196 R106 D166 R169 H193 S196 1.1.1.27 0003824,0004457,0004459,0005515,0005737,0005739,0005743,0005829,0006089,0006090,0016020,0016491,0016616,0019674,0019752,0019900,0042802,0045121,0051287,0070062,1990204 IC50=72050nM P07195 15117937 408 ATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKF