1sqq C 3.0 BS01 HEC C 1 Q44 I45 G48 L51 Y55 R80 H83 A84 A87 T126 A127 G130 L133 H182 P186 Q43 I44 G47 L50 Y54 R79 H82 A83 A86 T125 A126 G129 L132 H181 P185 H201 S205 K227 D228 E271 H200 S204 K226 D227 E270 ? 0005739,0005743,0006122,0008121,0009055,0016020,0016491,0020037,0022904,0031966,0045275,0046872,0048039,1902600 P00157 15312779 381 TNIRKSHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLYMHVGRGLYYGSYTFLETWNIGVILLLTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIMAIAMVHLLFLHETGSNNPTGISSDVDKIPFHPYYTIKDILGALLLILALMLLVLFAPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAFSILILALIPLLHTSKQRSMMFRPLSQCLFWALVADLLTLTWIGGQPVEHPYITIGQLASVLYFLLILVLMPTAGTIENKLLKW 1sqq C 3.0 BS02 HEC C 2 W31 G34 L37 H97 V98 R100 S106 W113 G116 V117 H196 L200 S205 N206 W30 G33 L36 H96 V97 R99 S105 W112 G115 V116 H195 L199 S204 N205 H201 S205 K227 D228 E271 H200 S204 K226 D227 E270 ? 0005739,0005743,0006122,0008121,0009055,0016020,0016491,0020037,0022904,0031966,0045275,0046872,0048039,1902600 P00157 15312779 382 TNIRKSHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLYMHVGRGLYYGSYTFLETWNIGVILLLTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIMAIAMVHLLFLHETGSNNPTGISSDVDKIPFHPYYTIKDILGALLLILALMLLVLFAPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAFSILILALIPLLHTSKQRSMMFRPLSQCLFWALVADLLTLTWIGGQPVEHPYITIGQLASVLYFLLILVLMPTAGTIENKLLKW 1sqq C 3.0 BS03 UQ2 C 1 F18 S35 S205 F220 D228 F17 S34 S204 F219 D227 H201 S205 K227 D228 E271 H200 S204 K226 D227 E270 ? 0005739,0005743,0006122,0008121,0009055,0016020,0016491,0020037,0022904,0031966,0045275,0046872,0048039,1902600 P00157 15312779 383 TNIRKSHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLYMHVGRGLYYGSYTFLETWNIGVILLLTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIMAIAMVHLLFLHETGSNNPTGISSDVDKIPFHPYYTIKDILGALLLILALMLLVLFAPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAFSILILALIPLLHTSKQRSMMFRPLSQCLFWALVADLLTLTWIGGQPVEHPYITIGQLASVLYFLLILVLMPTAGTIENKLLKW 1sqq C 3.0 BS04 OST C 1 F128 Y131 G142 A143 I146 I268 K269 P270 E271 Y273 F274 L294 F127 Y130 G141 A142 I145 I267 K268 P269 E270 Y272 F273 L293 H201 S205 K227 D228 E271 H200 S204 K226 D227 E270 ? 0005739,0005743,0006122,0008121,0009055,0016020,0016491,0020037,0022904,0031966,0045275,0046872,0048039,1902600 -logKd/Ki=7.82, Kd=15nM P00157 15312779 384 TNIRKSHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLYMHVGRGLYYGSYTFLETWNIGVILLLTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIIMAIAMVHLLFLHETGSNNPTGISSDVDKIPFHPYYTIKDILGALLLILALMLLVLFAPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAFSILILALIPLLHTSKQRSMMFRPLSQCLFWALVADLLTLTWIGGQPVEHPYITIGQLASVLYFLLILVLMPTAGTIENKLLKW 1sqq D 3.0 BS01 HEC D 1 C37 C40 H41 N105 L109 P110 P111 R120 Y126 L131 F153 G159 M160 P163 I164 C37 C40 H41 N105 L109 P110 P111 R120 Y126 L131 F153 G159 M160 P163 I164 7.1.1.8 0009055,0020037 P00125 15312779 242 SDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCSSCHSMDYVAYRHLVGVCYTEDEAKALAEEVEVQDGPNEDGEMFMRPGKLSDYFPKPYPNPEAARAANNGALPPDLSYIVRARHGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIGMAPPIYNEVLEFDDGTPATMSQVAKDVCTFLRWAAEPEHDHRKRMGLKMLLMMGLLLPLVYAMKRHKWSVLKSRKLAYRPPK 1sqq E 3.0 BS01 FES E 1 C139 H141 L142 C144 C158 C160 H161 S163 C139 H141 L142 C144 C158 C160 H161 S163 H161 H161 7.1.1.8 0008121,0016020,0051537 P13272 15312779 197 SHTDIKVPDFSDYRRPEVLDSTKSSKESSEARKGFSYLVTATTTVGVAYAAKNVVSQFVSSMSASADVLAMSKIEIKLSDIPEGKNMAFKWRGKPLFVRHRTKKEIDQEAAVEVSQLRDPQHDLERVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRKGPAPLNLEVPSYEFTSDDMVIVG