1sqi A 2.15 BS01 FE A 1 H183 H266 E349 H176 H243 E326 1.13.11.27 0000139,0003868,0005506,0005737,0005783,0005789,0005794,0006559,0006572,0009072,0016020,0016701,0042803,0046872,0051213 P32755 15301540 1450 GPKPERGRFLHFHSVTFWVGNAKQAASFYCNKMGFEPLAYKGLETGSREVVSHVIKQGKIVFVLCSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCEHIVQKARERGAKIVREPWVEEDKFGKVKFAVLQTYGDTTHTLVEKINYTGRFLPGFEAPTYKDTLLPKLPSCNLEIIDHIVGNQPDQEMESASEWYLKNLQFHRFWSVLRSIVVANYEESIKMPINEPASQIQEYVDYNGGAGVQHIALRTEDIITTIRHLRERGMEFLAVPSSYYRLLRENLKTSKIQVKENMDVLEELKILVDYDEKGYLLQIFTKPMQDRPTLFLEVIQRHNHQGFGAGNFNS 1sqi A 2.15 BS02 869 A 1 P239 Q251 H266 F336 F347 E349 F359 N363 F364 P221 Q228 H243 F313 F324 E326 F336 N340 F341 1.13.11.27 0000139,0003868,0005506,0005737,0005783,0005789,0005794,0006559,0006572,0009072,0016020,0016701,0042803,0046872,0051213 ic50<20nM -logKd/Ki=7.70, IC50<20nM P32755 15301540 1501 GPKPERGRFLHFHSVTFWVGNAKQAASFYCNKMGFEPLAYKGLETGSREVVSHVIKQGKIVFVLCSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCEHIVQKARERGAKIVREPWVEEDKFGKVKFAVLQTYGDTTHTLVEKINYTGRFLPGFEAPTYKDTLLPKLPSCNLEIIDHIVGNQPDQEMESASEWYLKNLQFHRFWSVLRSIVVANYEESIKMPINEPASQIQEYVDYNGGAGVQHIALRTEDIITTIRHLRERGMEFLAVPSSYYRLLRENLKTSKIQVKENMDVLEELKILVDYDEKGYLLQIFTKPMQDRPTLFLEVIQRHNHQGFGAGNFNS 1sqi B 2.15 BS01 FE B 1 H183 H266 E349 H177 H242 E325 1.13.11.27 0000139,0003868,0005506,0005737,0005783,0005789,0005794,0006559,0006572,0009072,0016020,0016701,0042803,0046872,0051213 P32755 15301540 1452 KGPKPERGRFLHFHSVTFWVGNAKQAASFYCNKMGFEPLAYKGLETGSREVVSHVIKQGKIVFVLCSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCEHIVQKARERGAKIVREPWVEEDKFGKVKFAVLQTYGDTTHTLVEKINYTGRFLPGFEAPTYKDTLLPKLPSCNLEIIDHIVGNQPDQEMESASEWYLKNLQFHRFWLRSIVVANYEESIKMPINEPASQIQEYVDYNGGAGVQHIALRTEDIITTIRHLRERGMEFLAVPSSYYRLLRENLKTSKIQVKENMDVLEELKILVDYDEKGYLLQIFTKPMQDRPTLFLEVIQRHNHQGFGAGNFNS 1sqi B 2.15 BS02 869 B 1 P239 N241 Q251 H266 L323 F336 F347 E349 F359 N363 F364 P220 N222 Q227 H242 L299 F312 F323 E325 F335 N339 F340 1.13.11.27 0000139,0003868,0005506,0005737,0005783,0005789,0005794,0006559,0006572,0009072,0016020,0016701,0042803,0046872,0051213 ic50<20nM P32755 15301540 1502 KGPKPERGRFLHFHSVTFWVGNAKQAASFYCNKMGFEPLAYKGLETGSREVVSHVIKQGKIVFVLCSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCEHIVQKARERGAKIVREPWVEEDKFGKVKFAVLQTYGDTTHTLVEKINYTGRFLPGFEAPTYKDTLLPKLPSCNLEIIDHIVGNQPDQEMESASEWYLKNLQFHRFWLRSIVVANYEESIKMPINEPASQIQEYVDYNGGAGVQHIALRTEDIITTIRHLRERGMEFLAVPSSYYRLLRENLKTSKIQVKENMDVLEELKILVDYDEKGYLLQIFTKPMQDRPTLFLEVIQRHNHQGFGAGNFNS